The Kelly Lab works on developing novel models to study normal human physiology and disease states, with an emphasis on ADME genes and their role in endobiotic/xenobiotic metabolism. The focus of his lab is on ex vivo modeling of human organ physiology and toxicological responses to drug/xenobiotic challenge. This research makes use of “organs on chips” or microphysiological systems (MPS) populated with primary and stem-cell derived cell types to recapitulate two key ADME organs, the liver and kidney. Recent work is extending MPS technologies to model human diseases, as well as how organs respond to the extreme environment of microgravity on the International Space Station.