ISCRM Faculty Shine a New Light on Scarring

October 12, 2018 | Categories: Research | Tagged: , , ,

Collaboration is the engine of scientific progress at UW Medicine and at the Institute of Stem Cell & Regenerative Medicine (ISCRM), where 130 researchers are developing stem cell-based approaches to treat diseases affecting nearly every organ and system in the human body.   Read More

UW Medicine Researchers Explore New Approaches to Treating Childhood Leukemia

October 1, 2018 | Categories: Research | Tagged: ,

Acute lymphocytic leukemia (ALL) is the most common type of childhood cancer, representing approximately 25% of cancer diagnoses in children 0-15. More than 3,000 new cases of ALL are diagnosed every year in the United States - and the incidence rate is rising. Read More

Researchers use stem cells to restore heart function in primates

July 2, 2018 | Categories: Research | Tagged: , ,

Results of a study published today in Nature Biotechnology suggest techniques that could treat patients with heart failure. Researchers at UW Medicine in Seattle have successfully used human stem cells to restore heart function in monkeys with heart failure. The findings suggest that the technique will be effective in patients with heart failure, the leading cause of death in the world. Read More

Understanding Alzheimers

May 23, 2018 | Categories: Research | Tagged: , , ,

New cell lines will allow researchers to probe the basic biology of Alzheimer’s. Currently, however, there are no treatments that can prevent or slow the progression of this memory-robbing disease, which affects more than 5 million Americans. One reason for this is that we really don’t know the cause of Alzheimer’s: It is known that brain cells that are crucial to forming new memories die. But we don’t know why. Read More

NIH accepts new ISCRM hESC lines

May 22, 2018 | Categories: Research

On May 9, 2018, three new ISCRM human embryonic stem cell (hESC) lines were accepted onto the NIH Stem Cell Registry.  Originated from donated human preimplantation blastocysts, Carol Ware derived the lines in medium that halted development in a preimplantation stage so they maintained a naive character.  All three lines have a good karyotype. The cell […] Read More

Robots grow mini-organs from human stem cells

May 17, 2018 | Categories: Research | Tagged: , ,

A robotic approach to mass-producing organoids could accelerate regenerative medicine research and drug discovery. An automated system that uses robots has been designed to rapidly produce human mini-organs derived from stem cells. Researchers at the University of Washington School of Medicine in Seattle developed the new system. Read More

Stem-cell study points to new approach to Alzheimer’s disease

March 1, 2018 | Categories: Research | Tagged: ,

Improving the trafficking of cellular proteins in brain cells holds possibilities for new treatments and even prevention for Alzheimer’s disease, results of a new study suggest. Researchers found that a compound that enhances the shuttling of proteins within cells reduced the production of forerunners of two proteins implicated in brain cell death. Read More

Researchers program biomaterials with ‘logic gates’ that release therapeutics in response to environmental triggers

January 16, 2018 | Categories: Research | Tagged: , ,

Drug treatments can save lives, but sometimes they also carry unintended costs. After all, the same therapeutics that target pathogens and tumors can also harm healthy cells. To reduce this collateral damage, scientists have long sought specificity in drug delivery systems: A package that can encase a therapeutic and will not disgorge its toxic cargo until it reaches the site of treatment — be it a tumor, a diseased organ or a site of infection. Read More

Study: Using big data to help fight a deadly cancer

January 12, 2018 | Categories: Research | Tagged: , ,

Researchers built an algorithm to discern which drugs might best combat patients’ individual cases of acute myeloid leukemia. The statistics are grim. For patients fighting an aggressive form of leukemia known as acute myeloid leukemia, or AML, doctors over the last 40 years have usually used a combination of two drugs to fight the disease, but it seldom cures it. Read More

Favorable interim results reported in stem-cell therapy trial

January 8, 2018 | Categories: Research | Tagged: , , ,

A therapy developed at UW shows promise in its first test in young boys who have an inherited deadly muscle disease. Favorable interim results have been announced in a small clinical trial of a stem-cell therapy to treat patients with a rare, deadly disease called myotubular myopathy. Read More