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Faculty headshot of Alessandro Bertero, PhD

Alessandro Bertero PhD

Laboratory Medicine and Pathology
Acting Assistant Professor

Email: abertero@uw.edu | Phone: 206.616.7675

Our long-term mission is to elucidate the gene regulatory mechanisms underpinning cardiac development and disease. Our current focus is the role of three-dimensional chromatin organization in normal and abnormal heart development, and in cardiomyopathy. We are also building novel genetic tools to probe the structure-function relationship of chromatin compartmentalization. Our work mainly relies on genetic engineering with CRISPR/Cas9, differentiation of human pluripotent stem cells into cardiomyocytes (hPSC-CMs), generation of 3D-engineered heart tissues, determination of nuclear architecture and function with genomic and imaging assays, and analysis of cardiac physiology.