Study: Using big data to help fight a deadly cancer

January 12, 2018 | Categories: Research | Tagged: , ,

Researchers built an algorithm to discern which drugs might best combat patients’ individual cases of acute myeloid leukemia. The statistics are grim. For patients fighting an aggressive form of leukemia known as acute myeloid leukemia, or AML, doctors over the last 40 years have usually used a combination of two drugs to fight the disease, but it seldom cures it. Read More

Favorable interim results reported in stem-cell therapy trial

January 8, 2018 | Categories: Research | Tagged: , , ,

A therapy developed at UW shows promise in its first test in young boys who have an inherited deadly muscle disease. Favorable interim results have been announced in a small clinical trial of a stem-cell therapy to treat patients with a rare, deadly disease called myotubular myopathy. Read More

Network of synthetic blood microvessels built

October 4, 2017 | Categories: Research | Tagged: , ,

Researchers are reporting significant progress in generating a 3-dimensional network of blood vessels that can be grown and manipulated in a laboratory.  Building vascular support for stem-cell repaired tissues or replacement organs will be vital to such regenerative therapies. Read More

Mini-kidney organoids reveal renal disease secrets

October 2, 2017 | Categories: Research | Tagged: , ,

Kidney organoids are revealing both the factors that influence the formation of kidney cysts, as well as how the disease progresses. The organoids are grown in labware from human stem cells. Polycystic kidney disease affects 12 million people. Until recently, scientists have been unable to recreate the progression of this human disease in a laboratory setting. Read More

Cancer trial: Expectation-setting gives way to hope

September 27, 2017 | Categories: Research | Tagged: , ,

Beginning four years ago, 15 women with incurable (metastatic triple-negative) breast cancer were enrolled in a unique clinical trial. It explored one concept of “precision medicine” – the suggestion that the brain power of multiple medical experts and the collection of an immense volume of data about each woman’s condition would yield the most personalized, customized care possible. Read More

A colony of human embryonic stem cells

Move over Gucci; researchers create designer stem cells

September 1, 2017 | Categories: Research | Tagged: , , ,

UW Medicine researchers recently lead a successful effort to create “designer” stem cells that might lead to advances in cancer and aging, they say. In a paper published in the journal PNAS, the scientists showed for the first time that a computer-generated protein can be inserted into stem cells to change their epigenetic memory, whose role is to ensure that a cell’s DNA sequence remains intact as it divides. Read More

Glia cells and neurons in the retina

Scientists regenerate retinal cells in mice

July 26, 2017 | Categories: Research | Tagged: , , , ,

Scientists have successfully regenerated cells in the retina of adult mice at the University of Washington School of Medicine in Seattle. Their results raise the hope that someday it may be possible to repair retinas damaged by trauma, glaucoma and other eye diseases. Their efforts are part of the UW Medicine Institute for Stem Cell […] Read More

Gene replacement therapy that works in dogs to be tested in children

May 18, 2017 | Categories: Research | Tagged: , , , ,

SEATTLE – KIRO 7 has learned of a revolutionary treatment, here in Seattle, that has saved the lives of dogs and is just months away from being tested in children. In video obtained by KIRO 7, dogs that were destined to die show no signs of the disease after a single infusion of gene-replacement therapy.  The […] Read More

Pioneering work on stem-cell therapies at UW deserves state support

April 9, 2017 | Categories: Research | Tagged: , , , , ,

IF you have a heart attack, hopefully you’ll survive. But your body will be forever changed. The world’s best doctors can’t undo the damage; instead, drugs and devices will help you live with a heart whose function too often dwindles. The body cannot replace muscle cells that die in heart attacks — maladies that help […] Read More

Transfer of the MTM1 gene into the weakened muscle tissue of dogs affected by myotubular myopathy restores muscle strength. The disease arises from a genetic mutation that disrupts the production of a protein needed for muscle function.

Gene therapy treats muscle-wasting disease in dogs

February 15, 2017 | Categories: Research | Tagged: , , ,

Work on gene therapy is showing significant progress for restoring muscle strength and prolonging lives in dogs with a previously incurable, inherited neuromuscular disease. UW Medicine Institute for Stem Cell and Regenerative Medicine scientists are leading the multi-institutional research effort. The disease arises from a mutation in genes that normally make a protein, called myotubularin, […] Read More