The Heart of Stem Cell Research

August 4, 2014 | Categories: Research | Tagged: ,

ISCRM’s Drs. Chuck Murry, Michael Laflamme and April Stempien-Otero discuss stem cells and heart regeneration in the latest podcast at UW Medicine Pulse. Listen to the episode here. Read More

Dr. Michael Laflamme

Scientists regenerate heart muscle in primates

April 30, 2014 | Categories: Research | Tagged: , ,

Findings bring stem cell therapy for damaged hearts closer to clinical trials In a major advance, researchers at the University of Washington have successfully restored damaged heart muscle of monkeys using heart cells created from human embryonic stem cells. The results of the experiment appear in the April 30 advanced online edition of the journal Nature. The findings […] Read More

ISCRM Faculty Member, Dr. Phil Horner, Featured on UW|360

April 24, 2014 | Categories: Research | Tagged: ,

Phil Horner, PhD, Associate Professor of Neurological Surgery at the UW, is working on a unique approach to restoring limb function after chronic spinal cord injury. Dr. Horner and his colleagues are researching how stem cell therapy and stimulation can be used together to restore limb function for people suffering from paralysis after a spinal […] Read More

Julie Mathieu (left)

Proteins that control energy use necessary to form stem cells

March 21, 2014 | Categories: Research | Tagged: , , ,

Findings advance efforts to reprogram mature cells for organ repair Two proteins that control how cells break down glucose play a key role in forming human stem cells, University of Washington researchers have found. The finding has implications for future work in both regenerative medicine and cancer therapy. A report on this research appears online March 20 […] Read More

Dr. Carol Ware at work in her laboratory at the Institute for Stem Cell and Regenerative Medicine

New cell line should accelerate embryonic stem cell research

March 10, 2014 | Categories: Research | Tagged: , ,

These cells appear at the earliest stages of an embryo and can form all human cell types University of Washington researchers have created a line of human embryonic stem cells with the ability to develop into a far broader range of tissues than most existing cell lines. “These cells will allow us to gain a […] Read More

"The contribution of the women enrolling in this trial is invaluable and their decision to participate

Study’s ‘panomic’ approach to advanced breast cancer

March 3, 2014 | Categories: Research | Tagged: , , ,

Trial enrollees sought; effort involves sharing tumors’ responses to therapy in massive public online database. Ten women with advanced breast cancer will participate in one of the most intensive clinical trials ever conducted to identify molecular changes in individual tumors and to understand the strategies cancers adopt to escape chemotherapy. The study is seeking enrollees. University of […] Read More

UW researchers developing patch for damaged hearts

February 14, 2014 | Categories: Research | Tagged: ,

Five million Americans are living with heart disease, heart failure and 715,000 will have a heart attack this year. Now researchers at the University of Washington are working on a new way to repair damaged hearts with a biological band-aid. Read More

Childers displays a dog family tree showing those affected and unaffected by an inherited muscle disorder similar to X-linked myotubular myopathy in people.

Gene therapy leads to robust improvements in animal model of fatal muscle disease

January 22, 2014 | Categories: Research | Tagged: , ,

January 22, 2014 Preclinical studies show that gene therapy can improve muscle strength in small- and large-animal models of a fatal congenital childhood disease know as X-linked myotubular myopathy. The findings, appearing  as the cover story in the January 22, 2014 issue of Science Translational Medicine, also demonstrate the feasibility of future clinical trials of gene therapy for […] Read More

Stained bone marrow aspirate from a patient with acute lymphoblastic leukemia.

Gene for most common childhood cancer identified

September 9, 2013 | Categories: Research | Tagged: , ,

September 9, 2013 An aberrant gene has been found to cause the most common childhood cancer in the world, pre-B cell acute lymphoblastic leukemia. The gene, PAX5, has long been known to be involved in acute lymphoblastic leukemia.  The new study indicates a mutation in the gene alone is sufficient to eventually cause the disease, […] Read More

Laboratory fruit flies are used for quick screening of candidate drug treatments for Duchenne muscular dystrophy.

Burnt sugar-derivative reduces muscle wasting in fly and mouse models of muscular dystrophy

August 1, 2013 | Categories: Research | Tagged: , , , ,

A trace substance in caramelized sugar, when purified and given in appropriate doses, improves muscle regeneration in a mouse model of Duchenne muscular dystrophy. The findings are published Thursday (Aug. 1) in the journal Skeletal Muscle. Morayma Reyes, professor of pathology and laboratory medicine, and Hannele Ruohola-Baker, professor of biochemistry and associate director of the Institute […] Read More