Young Lab Links Loss of SORL1 Gene to Increased Alzheimer’s Risk

June 2, 2020 | Categories: Research | Tagged: , , ,

To overcome the inherent challenges in studying the brain, one ISCRM team used stem cell technology to implicate a gene known as SORL1 in some types of Alzheimer’s and to shed new light on why many promising treatments for this disease have hit dead ends in clinical trials. Read More

With NIH Funding, Freedman Lab to Use Kidney Organoids to Predict Adverse Effects of Genome Editing

October 1, 2019 | Categories: Announcements, Award, Research | Tagged: , , , ,

Nearly 40 million Americans are impacted by chronic kidney disease, a family of progressive conditions associated with widespread health complications, including higher risk for heart disease. Read More

Intestinal organoid

With CRISPR, Modeling Disease in Mini Organs

May 6, 2016 | Categories: Research | Tagged: , , , ,

Traditionally, gene therapy efforts have attempted to treat genetic diseases by modifying DNA inside a patient’s body, but it has been a challenge to deliver the genetic material to all the target tissue, let alone to do so safely. But in recent years, advances in gene editing and stem cell research have enabled scientists to […] Read More