Aided by Stem Cells, ISCRM Researchers Identify a Suspect in the Case of Infertility

February 7, 2019 | Categories: Core Faculty, Research, Uncategorized | Tagged: , ,

Of all the mysteries surrounding the beginning of human life, one question has drawn particular interest from researchers at the Institute for Stem Cell and Regenerative Medicine (ISCRM). Simply put, for women who are unable to get pregnant, what is happening at the cellular level that is preventing life from taking hold? Finding an answer […] Read More

A colony of human embryonic stem cells

Move over Gucci; researchers create designer stem cells

September 1, 2017 | Categories: Research | Tagged: , , ,

UW Medicine researchers recently lead a successful effort to create “designer” stem cells that might lead to advances in cancer and aging, they say. In a paper published in the journal PNAS, the scientists showed for the first time that a computer-generated protein can be inserted into stem cells to change their epigenetic memory, whose role is to ensure that a cell’s DNA sequence remains intact as it divides. Read More

Deepkiran Singh

Stem cell research gets undergrads out of classroom

March 23, 2016 | Categories: Research | Tagged: , ,

Students help conduct intensive, real-world research at UW Medicine lab UW undergraduate Randy Lu grasps a pair of tweezers in each hand. His fingers make imperceptible movements as he dissects the tiny abdomen of a fruit fly. The tweezers and Lu’s hands look garishly large next to the insect, which is a mere speck in […] Read More

New book published on regenerative medicine for degenerative muscle diseases

January 12, 2016 | Categories: Announcements | Tagged: , , , , ,

Congratulations to ISCRM’s Casey Childers and Hannele Ruohola-Baker who are contributing authors of a new book entitled Regenerative Medicine for Muscle Diseases. The book, edited by Casey Childers, delves into the cutting-edge research having to do with degenerative skeletal disorders, such as Duchenne muscular dystrophy and congenital myopathy, and gene replacement therapy and stem cell […] Read More

Drs. Ruohola-Baker

Changes in metabolites can regulate earliest stages of development

November 16, 2015 | Categories: Research | Tagged: , , ,

Changes in cellular metabolites have been shown to regulate embryonic stem cell development at the earliest stages of life. Metabolites are simple compounds generated during life-sustaining chemical activities in cells. The recent findings, discovered by members of the Ruohola-Baker Lab, should improve scientists’ ability to use embryonic stem cells to grow new tissues and organs to replace […] Read More

Kavitha T. Kuppusamy led a study of a molecular switch that promotes heart cell maturation.

Molecular switch matures heart cells derived from stem cells

May 12, 2015 | Categories: Research | Tagged: , , ,

Discovery may prove a major advance in the development of stem cell treatments for heart disease A molecular switch that seems to be essential  for embryonic heart cells to grow into more mature, adult-like heart cells has been discovered. The discovery should help scientist better understand how human hearts mature. Of particular interest to stem […] Read More

At a University of Washington stem cell research lab

Dying cells can protect their stem cells from destruction

May 11, 2015 | Categories: Research | Tagged: , ,

An SOS signal from dying daughter cells allows their mother stem cells to protect themselves from radiation and chemotherapy damage Cells dying as the result of radiation exposure or chemotherapy can send a warning to nearby stem cells. The chemical signal allows the stem cells to escape the same fate, University of Washington researchers report […] Read More

Julie Mathieu (left)

Proteins that control energy use necessary to form stem cells

March 21, 2014 | Categories: Research | Tagged: , , ,

Findings advance efforts to reprogram mature cells for organ repair Two proteins that control how cells break down glucose play a key role in forming human stem cells, University of Washington researchers have found. The finding has implications for future work in both regenerative medicine and cancer therapy. A report on this research appears online March 20 […] Read More

Laboratory fruit flies are used for quick screening of candidate drug treatments for Duchenne muscular dystrophy.

Burnt sugar-derivative reduces muscle wasting in fly and mouse models of muscular dystrophy

August 1, 2013 | Categories: Research | Tagged: , , , ,

A trace substance in caramelized sugar, when purified and given in appropriate doses, improves muscle regeneration in a mouse model of Duchenne muscular dystrophy. The findings are published Thursday (Aug. 1) in the journal Skeletal Muscle. Morayma Reyes, professor of pathology and laboratory medicine, and Hannele Ruohola-Baker, professor of biochemistry and associate director of the Institute […] Read More

A colony of human embryonic stem cells.

Embryonic stem cells shift metabolism in a cancer-like way upon implanting in the uterus

March 23, 2012 | Categories: Research | Tagged: ,

March 23, 2012 Shortly after a mouse embryo starts to form, some of its stem cells undergo a dramatic metabolic shift to enter the next stage of development, Seattle researchers report today. These stem cells start using and producing energy like cancer cells. This discovery is published today in EMBO, the European Molecular Biology Organization journal. […] Read More