Priming the Heart for Regeneration

January 10, 2022 | Categories: Research | Tagged: , , ,

In 2015, a team of inquisitive young scientists, absorbed in the study of metabolism, regeneration, and biological development, set out to answer a question. Could the way cells produce energy help explain why certain organisms have an envious ability to regenerate heart tissue after injury? And, if so, could that knowledge be used to help heal human hearts? Read More

Green and purple stained organoid

ISCRM Research Sheds New Light on COVID-19 and Kidney Health

December 2, 2021 | Categories: Core Faculty, Research, Uncategorized | Tagged: , , ,

ISCRM researchers use kidney organoids to demonstrate that COVID-19 is capable of infecting kidney cells directly and test whether a synthetic protein designed by the Institute for Protein Design (IPD) might be capable of preventing infection. Read More

three scientists in a lab

Undergraduate Students on the Hunt for Cancer Killing Molecules

November 3, 2021 | Categories: Core Faculty | Tagged: , ,

Described in the journal Cells, a multi-year effort to identify molecules that target cancer cells gave UW undergraduates real-world laboratory experience. Read More

Julie Mathieu

New Investigator Award for Julie Mathieu Funds Collaborative Cancer Research

June 11, 2021 | Categories: Award, Research | Tagged: , , , ,

Fueled in part by a New Investigator Award from the Cancer Consortium, ISCRM faculty member Julie Mathieu, PhD is partnering with scientists at the Institute for Protein Design and Fred Hutch to develop new treatments for renal cell carcinoma. Read More

Supercharging Antibodies for Better Medicine

April 2, 2021 | Categories: Uncategorized | Tagged: , , , ,

Researchers from the Ruohola-Baker Lab have collaborated with the Institute for Protein Design on a technology in which designed proteins assemble antibodies in nanocage structures, increasing their potency against cancer, COVID-19, and other diseases. Read More

Insights on Genetic Causes of SIDS-linked Disease Published in Nature Communications

October 14, 2019 | Categories: Research | Tagged: , ,

Each year, according to the CDC, approximately 3,600 infant deaths in the United States are attributed to Sudden Unexplained Infant Death Syndrome (SUIDS) – an umbrella category that includes Sudden Infant Death Syndrome (SIDS). Read More

ISCRM and the UW School of Dentistry Reveal New Findings About the Nature of Stem Cells in Human Teeth

February 22, 2019 | Categories: Research | Tagged: , , ,

Long before Hannele Ruohola-Baker became a leading stem cell researcher, she was a young hockey player skating on the frozen ponds of her native Finland. When she was ten years old, she lost a tooth to an errant puck. “I’d say that’s when my interest in regenerating teeth began,” says Dr. Ruohola-Baker, now a Professor of Biochemistry and Associate Director of the UW Medicine Institute for Stem Cell and Regenerative Medicine (ISCRM). Read More

Aided by Stem Cells, ISCRM Researchers Identify a Suspect in the Case of Infertility

February 7, 2019 | Categories: Core Faculty, Research | Tagged: ,

February 7, 2019 Of all the mysteries surrounding the beginning of human life, one question has drawn particular interest from researchers at the Institute for Stem Cell and Regenerative Medicine (ISCRM). Simply put, for women who are unable to get pregnant, what is happening at the cellular level that is preventing life from taking hold? […] Read More

A colony of human embryonic stem cells

Move over Gucci; researchers create designer stem cells

September 1, 2017 | Categories: Research | Tagged: , , ,

UW Medicine researchers recently lead a successful effort to create “designer” stem cells that might lead to advances in cancer and aging, they say. In a paper published in the journal PNAS, the scientists showed for the first time that a computer-generated protein can be inserted into stem cells to change their epigenetic memory, whose role is to ensure that a cell’s DNA sequence remains intact as it divides. Read More