Kairui Jiang is developing aptamer-based tools to isolate specific cell populations from human iPSC-derived neuromuscular cultures. In the Pun and Mack labs, he will apply an NRP2-binding aptamer to enrich […] Read More
Diseases of low bone mineral density resulted in over 477,000 deaths in 2020, with deaths disproportionately occurring in low socio-demographic-index countries. Most existing therapeutic approaches for low bone mineral density […] Read More
The muscle spindle is a skeletal muscle stretch receptor that is vital to proprioception, your body’s ability to sense its position in space. There are major gaps in our understanding […] Read More
As an ISCRMU fellow, Noah will research the potential of the use of electrophysiologic DNA gene editing in the creation of stem cell lines for improved cardiac remuscularizaton therapy. Specifically, […] Read More
Since their introduction in 2006, human iPSCs have enabled a generation of lineage-specific cell lines and organoids. However, bridging in vitro findings to whole-organism outcomes remains slow. Supported by an […] Read More
As an ISCRM REU Fellow, Birva Pinto will investigate the genetic mutation G159D in cardiac troponin C (cTnC) related to Dilated Cardiomyopathy (DCM), a disease that enlarges the heart chambers, […] Read More
Cystic Fibrosis (CF) is a life-limiting genetic disease caused by a mutation of CFTR, eventually leading to respiratory failure. With an ISCRM fellowship award, Jasime Villegas aims to create a CRISPR-Cas9 […] Read More
With ISCRM fellowship funding, Willow Chernoske will develop and conduct a proof of concept for a CRISPR-Cas12a biotinylation system designed by the Escobar Lab to determine the epigenetic mechanisms that […] Read More
To improve the field’s understanding of MBNL1-directed transcriptome maturation, Kalen Robeson will use human iPSC models to determine the role of MBNL1 in differentiation into skeletal muscle and to determine […] Read More
With her ISCRM fellowship, Brizzia Munoz Robles will develop a generalizable strategy to customize the biochemical properties of cell-laden biomaterials in 4D through functional protein photoassembly. The goal is to […] Read More