Miguel Ramalho-Santos, PhD, MSc
Canada 150 Research Chair in Developmental Epigenetics
Senior Investigator, Lunenfeld-Tanenbaum Research Institute
Professor of Molecular Genetics, University of Toronto
Our lab is interested in the molecular mechanisms that regulate development of the early mammalian embryo and in pluripotent embryonic stem cells, and how such mechanisms are modulated by environmental inputs. We have pioneered studies of developmental hypertranscription, a phenomenon whereby cells globally elevate nascent transcription during growth stages of high biosynthetic demand. We have recently shown that hypertranscription is pervasive in adult stem/progenitor cells across diverse organs during organ maintenance and regeneration.