Andrew B. Stergachis MD, PhD

UW Medicine/Medical Genetics, Genome Sciences
Associate Professor

Email: absterga@uw.edu | Phone:

Our group is motivated by the question of how alterations in gene regulation contribute to human disease. Genomics is rapidly emerging as a cornerstone of medicine, yet we currently have a limited understanding of how alterations within the non-coding genome contribute to human disease. Our lab aims to overcome this challenge by developing and applying novel epigenomic tools to study the impact of non-coding and epigenetic variation on human disease. Specifically, we leverage patient-derived cell systems, such as fibroblasts, lymphoblastoid cells, indued pluripotent stem cells (iPSCs), and iPSC-derived organoids and differentiated cells to study how patient-specific non-coding genetic variants contribute to their disease. We combine these patient-specific systems with novel long-read sequencing approaches that we are developing in our lab to study how patient-specific genetic variation contributes to human disease.