The Cardiac Systems Simulation (CardSS) Lab is developing new computational modeling and simulation techniques that can help decipher the underlying causes of cardiac arrhythmia and explore emerging opportunities for clinical treatment. In the realm of regenerative medicine, we are developing novel tools that will help the scientific community understand why arrhythmias occur following injection of new cardiomyocytes derived from stem cells to prompt cardiac remuscularization after myocardial infarction. If successful, this work will produce new solutions to eliminate potentially lethal side effects of cell therapy, paving the way towards clinical feasibility. Our team is also working on a comprehensive framework for patient-specific modeling of arrhythmic disorders informed by measurements from hiPSC-CMs, clinical imaging, and finite element analysis. If successful, this project will pave the way towards a virtual heart platform suitable for studying each patient’s own unique arrhythmia with an unprecedented level of personalization.