With the support of the ISCRM Fellowship, Alex Elbahr will delineate the proteolytic processing of Nucleophosmin (NPM1) in hematopoietic stem cells (HSCs), employing recombinant NPM1 constructs and targeted protease assays. This study seeks to unravel the molecular underpinnings of NPM1 cleavage, offering potential insights into its role in HSC regulation and the pathogenesis of Acute Myeloid Leukemia (AML). The findings could pave the way for novel therapeutic interventions targeting AML.