In the Cardiac Systems Simulation Lab, Jamie Yang is conducting a computational study to establish the feasibility of using optogenetic stimulation to suppress ventricular arrhythmias associated with human pluripotent stem cell-derived cardiomyocyte (hPSC-CM) engraftment. Engraftment arrhythmias (EAs) are currently a major roadblock preventing in-human clinical trials of stem cell therapy that could regenerate tissue following a heart attack. In her project, she will further research the origin of EA development, characterize early EA dynamics, and establish the ideal opsin characteristics for experimental optogenetic suppression of EAs. The long-term goal is to develop a potential solution to engraftment-related arrhythmias that can be explored further in large animals and possibly humans.