As an ISCRMU fellow, Noah will research the potential of the use of electrophysiologic DNA gene editing in the creation of stem cell lines for improved cardiac remuscularizaton therapy. Specifically, Noah will conduct in-vitro investigation into the electrical, mechanical, and maturation state of the edited iPSC line known as MEDUSA (Modification of Electrophysiological DNA to Understand and Suppress Arrhythmia). A major challenge in cardiac remuscularization has been the generation of potentially arrhythmias from the cell graft region. MEDUSA aims to correct this by modifying cell electrophysiology in order to suppress the spontaneous depolarization behavior iPSC derived cardiomyocytes express that is believed to be the cause of these arrhythmias.
