Liver disease causes millions of deaths each year, yet scientists still lack the detailed structural information needed to 3D print a working liver. With support from ISCRM Fellowship, Dorice Goune aims to create high-resolution 3D maps of the liver’s smallest functional unit—the lobule—using advanced imaging and computational modeling. These maps will guide the bioprinting of anatomically accurate, perfusable liver tissue. This work could pave the way for new treatments, improve disease modeling, and bring us closer to printing functional human livers in the lab.