Li (Amily) Guo MD, PhD

UW Medicine/Hematology and Oncology
Assistant Professor
Assistant Member, Bloodworks Northwest Research Institute

Email: liamilyg@uw.edu | Phone: 206.568.2163

Dr. Guo’s lab is committed to advancing our understanding of platelets’ immune functions in both health and disease, and pioneering next-generation platelet-centered cell therapies. Platelets, which are anucleate cells derived from hematopoietic stem cell megakaryocytes, are produced at a rate of approximately 100 billion cells per day in adults. Abnormal platelet number and functions play crucial roles in various conditions such as cardiovascular diseases, bleeding disorders, cancer, infections, and autoimmune diseases. Our research focuses on understanding the function and regulation of Major Histocompatibility Complex (MHC) class I in platelets, and its impact on adaptive immune responses, unveiling the actin cytoskeleton dynamics in platelet immune functions, and bioengineering of platelet-centered cell therapies from stem cells.