The Lin Lab is interested in understanding the epigenomic changes which occur in cardiovascular disease states. The lab employs the latest in second generation sequencing methods to identify various regulatory elements on a global scale on human samples collected from the operating room. Generated data are subsequently analyzed in the context of other big data from public repositories on a computer cluster. High throughput methods involving stem cell differentiated cardiomyocytes are employed for subsequent in vitro validation. Murine models are also utilized to study key genes within a physiological framework. The research of the lab thus involves procurement of samples in the clinical setting, computational biology, statistics, molecular biology, stem cell culturing, and mouse work. By exploring the epigenomic changes of cardiovascular disease states, the hope is that new avenues for therapies will be discovered.