Pharmacologic enhancement of retromer rescues endosomal pathology induced by defects in the Alzheimer’s gene SORL1

Stem Cell Reports, December 2023

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Recent Research

Enhancing immunogenic responses through CDK4/6 and HIF2α inhibition in Merkel cell carcinoma

Cell Press, December 2023

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Antigen perception in T cells by long-term Erk and NFAT signaling dynamics

PNAS, December 2023

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Probing cerebral malaria inflammation in 3D human brain microvessels

Cell Report, October 2023

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Derivation of Naïve Human Embryonic Stem Cells Using a CHK1 Inhibitor

Stem Cell Reviews and Reports, September 2023

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Single-cell census of human tooth development enables generation of human enamel

Developmental Cell, August 2023

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Targeting SERCA2 in organotypic epidermis reveals MEK inhibition as a therapeutic strategy for Darier disease

JCI Insight, August 2023

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CRaTER enrichment for on-target gene editing enables generation of variant libraries in hiPSCs

Journal of Molecular and Cellular Cardiology, May 2023

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Genetic mapping reveals Pou2af2/ OCA-T1-dependent tuning of tuft cell differentiation and intestinal type 2 immunity

Science Immunology, May 2023

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Spatiotemporal functional assembly of split protein pairs through a light-activated SpyLigation

Nature Chemistry, April 2023

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