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Anne Manicone MD

UW Pulmonary, Critical Care and Sleep Medicine
Associate Professor

Email: manicone@uw.edu | Phone: 206.598.4615


My research focuses on understanding the mechanisms by which leukocyte recruitment to the lung is regulated. In particular, I am characterizing the role of epilysin (also known as matrix metalloproteinase 28) in regulating macrophage recruitment to the lung, and I have uncovered a novel role for this proteinase in restraining early macrophage recruitment and in modulating macrophage activation. Ongoing work in my laboratory focuses on using proteomics to determine novel epilysin substrates that are involved in regulating macrophage influx and activation. Additional areas of interest include the role of macrophage subpopulations on regulating lung epithelial cell responses to bacterial products and development of acute lung injury.