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Brian J. Beliveau PhD

UW Genome Sciences
Assistant Professor

Email: beliveau@uw.edu | Phone: 206.543.7254

Our lab specializes in developing and applying new technologies to study spatial patterns of gene regulation and gene expression in cells and tissues. Our approaches include oligo-based in situ hybridization, quantitative microscopy, spatial transcriptomics, and the profiling of molecular interactions using next generation sequencing and quantitative proteomics. We aim to use cell-based differentiation systems to serve as models for the investigation of chromatin plasticity in developmental transitions, with a particular focus on enhancer biology and mechanisms of regulatory gene silencing. Our ultimate goal is to uncover broadly applicable mechanisms of gene regulation that help cells establish and maintain their proper identities and to understand how these mechanisms can be abrogated in the context of disease.