Professor Dayong Gao graduated (with the B.Sc. degree) from University of Science and Technology of China in 1983, and obtained Ph.D. in Mechanical Engineering and Biomedical Engineering in 1992 from Concordia University, Montreal, Canada. His research has been focused on the problems in thermal/fluid science and biomedical engineering with funding supports from NIH, NSF, Whitaker Foundation, American Cancer Society, American Heart Association, DoD, and various Industries or research institutions. He has published over 120 original full manuscripts and obtained 12 US patents in the following research areas:
Cryopreservation and fundamental cryobiology (mechanisms of cell cryoinjury and cryoprotection) of cells and tissues including: human and mammalian sperm, oocytes, embryos, pancreatic islets, bone marrow stem cells, umbilical cord blood, human platelets, skin, blood vessels/arteries, red blood cells, fatty cells, ovary tissues, and cornea.
Bio-heat-mass transfer and thermal stress in cells/tissues during cryopreservation: permeability of cell and artificial porous membranes, micro-heat and mass transfer across cell/artificial membranes and its activation energy, solidification/vitrification of biomaterials, intracellular ice formation and growth, thermal and mechanical properties of biomaterials, thermal stress and its-induced fracture in tissues/organs during cryopreservation processes, directional solidification of biomaterials.
Artificial kidney: investigating and developing a new generation of artificial kidney (hemodialyzers) with bio-functional and internal filtration ability (using both experimental and computational approaches) to treat the End Stage Kidney Failure disease.
Nano-technology/nano-fluid/Membrane Science: investigating and developing novel ceramic porous membranes with uniformly-distributed and identical nano-scale pores (nano-scale fabrication) for the blood purification (mass transfer) and the separation of bio-macromolecules (nano-scale). Developing novel technology for manufacturing porous membrane hollow fibers (polymer) by "Wet spinning technology" (nano-scale fabrication) for use in artificial kidney and artificial liver.
Development of optimal technology and equipment (e.g. cell micro-perfusion chamber, automated perfusion-washing machine for addition and removal of cryoprotectants in cells, directional solidification machine for freezing of biological cells and tissues) for cryopreservation and banking of cells and tissues as well as re-engineered tissues for transplantation.
Novel-microwave-irradiation-enhanced vitrification/glassification and rapid-uniform re-warming of biological systems.
Tissue engineering: (a) developing a novel bio-reactor (cell-foam) to expand hematopoietic stem cells derived from human bone marrow or umbilical cord blood for use in bone marrow transplantation and potential gene therapy; (b) developing a bio-reactor for use in the bio-functional artificial kidney.
Cardiovascular and blood research: (a) development of novel MRI imaging techniques to investigate the blood flow in blood vessels and its interaction with blood vessels, a well as blood flow in the porous membrane hollow fibers in the artificial kidney; (b) cryopreservation and micro-surgical implantation of arteries in bypass surgery (animal models); (c) blood coagulation and wound healing; and (d) freeze-drying of human red cells and platelets for transfusion.
Major clinical research collaborations with physicians and surgeons (for 12 years) to treat diseases: cryopreservation of pancreatic islets for pancreatic islet transplantation (treating diabetes), cryopreservation of sperm/oocytes/ovary tissues for artificial insemination/in vitro fertilization (treating infertility or for cancer patients before chemotherapy), cryopreservation of small elastic artery for coronary artery bypass surgery (treating heart disease), cryopreservation of bone marrow and umbilical cord blood for hematopoietic stem cell transplantation (treating cancers), cryopreservation of blood cells (red cells and platelets) for blood transfusion/banking (surgery, trauma, cancer treatment), cryopreservation of fatty cells and bones (plastic surgery), and development optimal hemodiafiltration conditions and a new generation of artificial kidney (treating end stage renal failure disease).