The culture of hepatocytes is critical for developing therapies to replace human-to-human liver transplants. One way to do this is in the form of hepatocyte organoids, which are generally cultured […] Read More
Hypertrophic cardiomyopathy (HCM) affects nearly 1 in 500 people in the US and causes the walls of the heart to thicken, leading to outcomes as severe as heart failure and […] Read More
Humans have a limited innate capacity to regenerate musculoskeletal tissues following digit or limb amputation. The Qu Lab uses the mouse digit tip model to investigate mammalian appendage regeneration. Current […] Read More
Chromosomal instability (CIN) typically triggers cell death or malignant transformation. How placental trophoblasts are paradoxically able to tolerate extensive aneuploidy without functional impairment in a non-cancerous context remains poorly understood. […] Read More
Vascular stability – the capacity of mature endothelium to maintain barrier integrity, resist aberrant sprouting, and support proper perfusion – is essential for tissue homeostasis. Loss of vascular stability is […] Read More
Myotonic dystrophy (DM) is a genetic disease caused by CTG sequence repeat expansion in the DMPK gene, resulting in toxic RNAs that cause loss of function of MBNL1 protein and […] Read More
Kairui Jiang is developing aptamer-based tools to isolate specific cell populations from human iPSC-derived neuromuscular cultures. In the Pun and Mack labs, he will apply an NRP2-binding aptamer to enrich […] Read More
Mammals are vulnerable to a number of diseases that cause blindness through permanent retinal cell loss. Previous work has shown that expression of the proneural transcription factor Ascl1 in mouse […] Read More
Sex hormones can influence healing outcomes in the knee meniscus. To study this as an undergraduate student, Elizabeth aims to investigate sex differences in the human meniscus cell response. Elizabeth […] Read More
How our bones develop influences our risk of osteoporosis and other skeletal disorders. In the Musculoskeletal Systems Biology Lab, led by Ronald Young Kwon, Hayden Bhavsar studies bone development by […] Read More