With an ISCRM fellowship award, Brenda Garibay investigates whether HP1BP3, an H1-like histone protein, is essential for epigenetic memory in heterochromatin. Using human iPSCs, she aims to uncover how HP1BP3 […] Read More
With support from the ISCRM fellowship, Sarah John aims to investigate how the dysfunction of TAOK1 kinase results in perturbed early brain development and macrocephaly. Sarah will utilize hiPSCs harboring […] Read More
Cystic Fibrosis (CF) is a life-limiting genetic disease caused by a mutation of CFTR, eventually leading to respiratory failure. With an ISCRM fellowship award, Jasime Villegas aims to create a CRISPR-Cas9 […] Read More
As an ISCRM Fellow, Scott Schactler is characterizing the microenvironment of the lncRNA Xist during X-chromosome inactivation using photocatalyst-powered super-resolution proximity-labeling tools. Using Oligonucleotide-directed proximity-interactome MAPing (O-MAP) in a cell […] Read More
Unlike non-mammalian vertebrates, hair cell damage in the mature mammalian cochlea leads to permanent hearing loss. There is great need for the discovery of new factors that promote hair cell […] Read More
In his fellowship project, Brad will investigate methods to generate spermatogonial cells (the base cell of spermatogenesis) from induced pluripotent stem cells using directed stem cell differentiation alongside a complex […] Read More
ISCRM fellowship funds will enable Morgan Jones to determine how a poised chromatin state is initially formed as well as how terminal effector and memory precursor CD8+ T cells maintain […] Read More
To improve the field’s understanding of MBNL1-directed transcriptome maturation, Kalen Robeson will use human iPSC models to determine the role of MBNL1 in differentiation into skeletal muscle and to determine […] Read More