Hypertrophic cardiomyopathy (HCM) affects nearly 1 in 500 people in the US and causes the walls of the heart to thicken, leading to outcomes as severe as heart failure and […] Read More
Humans have a limited innate capacity to regenerate musculoskeletal tissues following digit or limb amputation. The Qu Lab uses the mouse digit tip model to investigate mammalian appendage regeneration. Current […] Read More
Chromosomal instability (CIN) typically triggers cell death or malignant transformation. How placental trophoblasts are paradoxically able to tolerate extensive aneuploidy without functional impairment in a non-cancerous context remains poorly understood. […] Read More
Vascular stability – the capacity of mature endothelium to maintain barrier integrity, resist aberrant sprouting, and support proper perfusion – is essential for tissue homeostasis. Loss of vascular stability is […] Read More
Kairui Jiang is developing aptamer-based tools to isolate specific cell populations from human iPSC-derived neuromuscular cultures. In the Pun and Mack labs, he will apply an NRP2-binding aptamer to enrich […] Read More
Mammals are vulnerable to a number of diseases that cause blindness through permanent retinal cell loss. Previous work has shown that expression of the proneural transcription factor Ascl1 in mouse […] Read More
How our bones develop influences our risk of osteoporosis and other skeletal disorders. In the Musculoskeletal Systems Biology Lab, led by Ronald Young Kwon, Hayden Bhavsar studies bone development by […] Read More
Diseases of low bone mineral density resulted in over 477,000 deaths in 2020, with deaths disproportionately occurring in low socio-demographic-index countries. Most existing therapeutic approaches for low bone mineral density […] Read More
Left-right (L-R) patterning is essential for proper organ development, and its disruption causes heterotaxy, an abnormal arrangement of internal organs, often accompanied by congenital heart defects. Although loss of the […] Read More
The muscle spindle is a skeletal muscle stretch receptor that is vital to proprioception, your body’s ability to sense its position in space. There are major gaps in our understanding […] Read More