The muscle spindle is a skeletal muscle stretch receptor that is vital to proprioception, your body’s ability to sense its position in space. There are major gaps in our understanding […] Read More
My doctoral research investigates how a small RNA molecule, microRNA-192, guides human stem cells toward a pancreatic beta cell fate. Using a CRISPR-Cas9-engineered, inducible miRNA system, I aim to improve […] Read More
Current human kidney organoid models, derived from pluripotent stem cells, face significant limitations. They remain structurally immature, functionally incomplete, and often highly variable between batches, lacking the vascularization and specialized […] Read More
Skeletal muscle has an extraordinary ability to regenerate, but this process declines sharply with age and disease, leading to weakness and frailty. A major challenge is that the genetic programs […] Read More
Since their introduction in 2006, human iPSCs have enabled a generation of lineage-specific cell lines and organoids. However, bridging in vitro findings to whole-organism outcomes remains slow. Supported by an […] Read More
With support from the ISCRM Fellowship, Theresa is developing two complementary high-throughput single-cell techniques to investigate disease-associated enhancers in retinal organoids. Enhancers—noncoding DNA elements that regulate gene expression—have been linked to […] Read More
Liver disease causes millions of deaths each year, yet scientists still lack the detailed structural information needed to 3D print a working liver. With support from ISCRM Fellowship, Dorice Goune […] Read More
Like other organs, the heart forms scar tissue in response to stress or injury. Cardiac fibroblasts are the cells in the heart responsible for regulating production and degradation of scar […] Read More
Biological sex plays a role in meniscus injury and regeneration: females experience more tears and worse repair outcomes. As a first year graduate student in the Robinson Lab, Janie Johnson […] Read More