The culture of hepatocytes is critical for developing therapies to replace human-to-human liver transplants. One way to do this is in the form of hepatocyte organoids, which are generally cultured […] Read More
Tadpoles of closely related frog species Xenopus laevis and Xenopus tropicalis exhibit varying capacities of regenerative success depending on their developmental stage and structure type, making them an excellent model for tissue regeneration. Previous […] Read More
One of the critical processes in developing and regenerating organs is endoreplication: DNA synthesis without cell division. Despite its potential to increase cell size, whether and how endoreplication influences organ […] Read More
As an ISCRMU fellow, Noah will research the potential of the use of electrophysiologic DNA gene editing in the creation of stem cell lines for improved cardiac remuscularizaton therapy. Specifically, […] Read More
As an ISCRM fellow, Olivia will investigate human placental cells’ tolerance to severe genomic stress. Compared to their parental human pluripotent stem cells (hPSCs), trophoblast stem cells (TSCs) and placentas […] Read More
In the Zheng Lab, Sumin Hong is developing computational tools to analyze endothelial cell (EC) behavior in 3D brain microvessels following traumatic brain injury (TBI). Her work focuses on creating […] Read More
As an ISCRMU Fellow, Aleah will investigate the relationship between neurons and microglia. In their resting state, microglia support neuronal health and network formation; however, it remains unclear whether they […] Read More
With the support of the ISCRM Fellowship, Alex Elbahr will delineate the proteolytic processing of Nucleophosmin (NPM1) in hematopoietic stem cells (HSCs), employing recombinant NPM1 constructs and targeted protease assays. […] Read More
With funding from the ISCRM Undergraduate Fellowship, Sahana Subramanian will identify healthy and unhealthy endothelial cell flow conditions within a perfusable engineered heart tissue, hypothesizing that physiologically relevant shear stress […] Read More
As an ISCRM Undergraduate Fellow, Lily Nguyen aims to address the role of two core signaling pathways (Notch and Hedgehog) in maintaining the structural integrity of the developing nervous system. […] Read More