Two groups of stained neutrophil cells: the left group shows normal-shaped nuclei, while the right group shows nuclei with abnormal shapes, indicating lamin B1 deletion (Pelger-Huët anomaly).

Deletion of Lamin B1 Linked to Nuclear Abnormalities Seen in Cancer

March 11, 2022 | Categories: Research, Uncategorized | Tagged: , ,

Using gene-editing tools to decrease expression of lamin B1 in two stem cell models, the researchers show that deletion of lamin B1 causes change in stem cell function and nuclear shape – and contributes to leukemia progression. Read More

Diagram showing three columns comparing B cell development: non-leukemic, leukemic without treatment (PAX5 mutation), and leukemic with treatment (PAX2 rescue). Includes a kidney, bone, and activation pathway illustration.

UW Medicine Researchers Explore New Approaches to Treating Childhood Leukemia

October 1, 2018 | Categories: Research | Tagged: ,

Acute lymphocytic leukemia (ALL) is the most common type of childhood cancer, representing approximately 25% of cancer diagnoses in children 0-15. More than 3,000 new cases of ALL are diagnosed every year in the United States - and the incidence rate is rising. Read More