New Gene Therapy for Muscular Dystrophy Offers Hope
July 17, 2024 | Categories: Core Faculty, Research |A new gene therapy treatment for Duchenne muscular dystrophy (DMD) shows promise of not only arresting the decline of the muscles of those affected by this inherited genetic disease, but perhaps, in the future, repairing those muscles. Read More
Designed Proteins Guide Stem Cells to Form Blood Vessels
June 11, 2024 | Categories: Core Faculty, Research |UW researchers have used computer-designed proteins to direct human stem cells to form new blood vessels in the lab, offering new hope for repairing damaged hearts, kidneys, and other organs. Read More
Why Tiny Changes in Protein Structure Can Lead to Big Problems for the Heart
May 2, 2024 | Categories: Research, Uncategorized |An NIH-funded collaboration involving ISCRM researchers has published a study describing how complementary areas of expertise produced new insights about hypertrophic cardiomyopathy at the protein, cell, and tissue levels. Read More
Freedman Lab Discovers Promising New Therapeutic for PKD in Tailor-Made Organoids
April 4, 2024 | Categories: Core Faculty, Research |In a new study published in Cell Stem Cell, the Freedman Lab shows that a drug known to be safe in humans inhibits the growth of cysts in gene-edited organoids with polycystic kidney disease. Read More
Berndt Lab Machine Learning Model Sets a New Pace in Protein Sensor Design
March 26, 2024 | Categories: Core Faculty, Research |Over the course of a multiyear, collaborative investigation, researchers in the Berndt Lab showed that their trained machine learning models correctly predicted several variants of the calcium indicator GCaMP with record-setting speed and accuracy, outperforming all previous generations of these sensors. Read More
Protein-Based Biomaterial Protects Injected Cells, Improves Engraftment
March 13, 2024 | Categories: Core Faculty, Research |Research led by Cole DeForest, PhD in collaboration with Chuck Murry, MD, PhD and Kelly Stevens, PhD details a new protein-based biomaterial that could help improve engraftment and function following injectable cell therapies. Read More
$7.3 Million NIH Grant Funds Effort to Advance Kidney Microphysiological Testing Platforms
February 12, 2024 | Categories: Core Faculty, Research |NIH Funding will allow ISCRM faculty members Ed Kelly and Beno Freedman to lead the effort to advance kidney-on-a-chip and organoid testing technology and submit a 3D engineered platform for FDA approval. Read More
Kueh Lab Studies How and When Immune Cells Form Pathogen Memories
February 1, 2024 | Categories: Core Faculty, Research |Research from the Kueh Lab shows infection-fighting blood cells can change course to become long-lived memory cells instead of short-lived killer cells. Read More
Study from Kueh Lab Describes Surprising Agility in T Cell Threat Assessment
January 11, 2024 | Categories: Core Faculty, Research |New research from the Kueh Lab, published in the journal PNAS, reveals surprising insights about the signaling circuitry that allows T cells to elicit tailored responses to a diverse range of threats and proposes a model for future study. Read More
Finding a Sweet Spot for Cultivating Embryonic Cell Lines
January 2, 2024 | Categories: Core Faculty, Research |Research from Julie Mathieu and Carol Ware adds to understanding of human early development and the clinical utility of late naïve hESC derived directly from blastocysts. Read More