Designed Proteins Guide Stem Cells to Form Blood Vessels

June 11, 2024 | Categories: Core Faculty, Research | Tagged: , ,

UW researchers have used computer-designed proteins to direct human stem cells to form new blood vessels in the lab, offering new hope for repairing damaged hearts, kidneys, and other organs. Read More

Meet the 2024 Tietze Award Winners

May 24, 2024 | Categories: Award, Core Faculty | Tagged: , ,

ISCRM Associate Director Nate Sniadecki, PhD, Professor of Mechanical Engineering and Hichem Tasfaout, PhD, Acting Assistant Professor, Neurology have received prestigious awards from the John H. Tietze Foundation Trust that will help fuel promising research underway in their labs. Read More

Why Tiny Changes in Protein Structure Can Lead to Big Problems for the Heart

May 2, 2024 | Categories: Research, Uncategorized | Tagged: , , ,

An NIH-funded collaboration involving ISCRM researchers has published a study describing how complementary areas of expertise produced new insights about hypertrophic cardiomyopathy at the protein, cell, and tissue levels. Read More

Freedman Lab Discovers Promising New Therapeutic for PKD in Tailor-Made Organoids

April 4, 2024 | Categories: Core Faculty, Research | Tagged: , , ,

In a new study published in Cell Stem Cell, the Freedman Lab shows that a drug known to be safe in humans inhibits the growth of cysts in gene-edited organoids with polycystic kidney disease. Read More

Leadership News

April 1, 2024 | Categories: Core Faculty

ISCRM Dr. Charles “Chuck” Murry has been appointed to lead stem-cell research at the University of Southern California’s Keck School of Medicine. He will start there in August. Read More

Berndt Lab Machine Learning Model Sets a New Pace in Protein Sensor Design

March 26, 2024 | Categories: Core Faculty, Research | Tagged: , ,

Over the course of a multiyear, collaborative investigation, researchers in the Berndt Lab showed that their trained machine learning models correctly predicted several variants of the calcium indicator GCaMP with record-setting speed and accuracy, outperforming all previous generations of these sensors. Read More

Protein-Based Biomaterial Protects Injected Cells, Improves Engraftment

March 13, 2024 | Categories: Core Faculty, Research | Tagged: , , , ,

Research led by Cole DeForest, PhD in collaboration with Chuck Murry, MD, PhD and Kelly Stevens, PhD details a new protein-based biomaterial that could help improve engraftment and function following injectable cell therapies. Read More

$7.3 Million NIH Grant Funds Effort to Advance Kidney Microphysiological Testing Platforms

February 12, 2024 | Categories: Core Faculty, Research | Tagged: , , , , ,

NIH Funding will allow ISCRM faculty members Ed Kelly and Beno Freedman to lead the effort to advance kidney-on-a-chip and organoid testing technology and submit a 3D engineered platform for FDA approval. Read More

Kueh Lab Studies How and When Immune Cells Form Pathogen Memories

February 1, 2024 | Categories: Core Faculty, Research | Tagged: ,

Research from the Kueh Lab shows infection-fighting blood cells can change course to become long-lived memory cells instead of short-lived killer cells. Read More

Study from Kueh Lab Describes Surprising Agility in T Cell Threat Assessment

January 11, 2024 | Categories: Core Faculty, Research | Tagged: , ,

New research from the Kueh Lab, published in the journal PNAS, reveals surprising insights about the signaling circuitry that allows T cells to elicit tailored responses to a diverse range of threats and proposes a model for future study. Read More