Fluorescent microscopic image of a circular group of cells with green, blue, and purple highlights on a black background, showing cell boundaries and internal structures.

Freedman Lab Tests a Promising mTOR Inhibitor in PKD Organoids

January 23, 2025 | Categories: Research | Tagged: , , ,

The study results suggest the molecule at the center of the study may be safer at higher doses and therefore more potent against harmful cysts. Read More

An illustration shows a curved organoid with fluid entering; green cells absorb fluid, causing the organoid to expand and form a cyst, representing cyst growth in polycystic kidney disease (PKD). Arrows indicate the direction of flow and expansion.

Research from Freedman Lab Reveals Surprising Finding About Common Cause of Kidney Disease

January 5, 2023 | Categories: Core Faculty, Research | Tagged: , ,

A paper from the Freedman Lab, published this week in Nature Communications, reveals a surprising finding about the way cysts form in PKD organoids, a discovery that could have clinical implications. Read More

Primary cilia (red) lining the surface of human kidney organoids (gray).

Freedman Lab Explores the Role Cilia Play in Signaling, Cell Fate, and Disease Development

April 27, 2022 | Categories: Research | Tagged: , , , , , ,

In the Freedman Lab, knocking out primary cilia reveals insights about the role the organelles play in cell fate and disease development. Read More