A paper from the Freedman Lab, published this week in Nature Communications, reveals a surprising finding about the way cysts form in PKD organoids, a discovery that could have clinical implications. Read More
In the Freedman Lab, knocking out primary cilia reveals insights about the role the organelles play in cell fate and disease development. Read More
ISCRM researchers use kidney organoids to demonstrate that COVID-19 is capable of infecting kidney cells directly and test whether a synthetic protein designed by the Institute for Protein Design (IPD) might be capable of preventing infection. Read More
Nearly 40 million Americans are impacted by chronic kidney disease, a family of progressive conditions associated with widespread health complications, including higher risk for heart disease. Read More
A robotic approach to mass-producing organoids could accelerate regenerative medicine research and drug discovery. An automated system that uses robots has been designed to rapidly produce human mini-organs derived from stem cells. Researchers at the University of Washington School of Medicine in Seattle developed the new system. Read More
Kidney organoids are revealing both the factors that influence the formation of kidney cysts, as well as how the disease progresses. The organoids are grown in labware from human stem cells. Polycystic kidney disease affects 12 million people. Until recently, scientists have been unable to recreate the progression of this human disease in a laboratory setting. Read More
Textbook diagrams of cells show a cursory membrane, nucleus and mitochondria. They have never adequately conveyed cells’ variation and complexity. Seattle’s Allen Institute for Cell Science has unveiled an online portal with stunning […] Read More
Traditionally, gene therapy efforts have attempted to treat genetic diseases by modifying DNA inside a patient’s body, but it has been a challenge to deliver the genetic material to all […] Read More
Stem-cell biology and gene editing advances offer hope for kidney regeneration, drug discovery Mini-kidney organoids that re-create human kidney disease have now been grown in laboratory petri dishes. The achievement, […] Read More