Research from Freedman Lab Reveals Surprising Finding About Common Cause of Kidney Disease

January 5, 2023 | Categories: Core Faculty, Research | Tagged: , ,

A paper from the Freedman Lab, published this week in Nature Communications, reveals a surprising finding about the way cysts form in PKD organoids, a discovery that could have clinical implications. Read More

Primary cilia (red) lining the surface of human kidney organoids (gray).

Freedman Lab Explores the Role Cilia Play in Signaling, Cell Fate, and Disease Development

April 27, 2022 | Categories: Research | Tagged: , , , , , ,

In the Freedman Lab, knocking out primary cilia reveals insights about the role the organelles play in cell fate and disease development. Read More

Green and purple stained organoid

ISCRM Research Sheds New Light on COVID-19 and Kidney Health

December 2, 2021 | Categories: Core Faculty, Research, Uncategorized | Tagged: , , ,

ISCRM researchers use kidney organoids to demonstrate that COVID-19 is capable of infecting kidney cells directly and test whether a synthetic protein designed by the Institute for Protein Design (IPD) might be capable of preventing infection. Read More

With NIH Funding, Freedman Lab to Use Kidney Organoids to Predict Adverse Effects of Genome Editing

October 1, 2019 | Categories: Announcements, Award, Research | Tagged: , , , ,

Nearly 40 million Americans are impacted by chronic kidney disease, a family of progressive conditions associated with widespread health complications, including higher risk for heart disease. Read More

Robots grow mini-organs from human stem cells

May 17, 2018 | Categories: Research | Tagged: , ,

A robotic approach to mass-producing organoids could accelerate regenerative medicine research and drug discovery. An automated system that uses robots has been designed to rapidly produce human mini-organs derived from stem cells. Researchers at the University of Washington School of Medicine in Seattle developed the new system. Read More

Mini-kidney organoids reveal renal disease secrets

October 2, 2017 | Categories: Research | Tagged: , ,

Kidney organoids are revealing both the factors that influence the formation of kidney cysts, as well as how the disease progresses. The organoids are grown in labware from human stem cells. Polycystic kidney disease affects 12 million people. Until recently, scientists have been unable to recreate the progression of this human disease in a laboratory setting. Read More

Allen Institute researchers have found astonishing variability of the intracellular organization inside human stem cells.

New portal vividly reveals the diversity of cell structures

April 5, 2017 | Categories: Announcements | Tagged: , , , , ,

Textbook diagrams of cells show a cursory membrane, nucleus and mitochondria. They have never adequately conveyed cells’ variation and complexity. Seattle’s Allen Institute for Cell Science has unveiled an online portal with stunning […] Read More

Intestinal organoid

With CRISPR, Modeling Disease in Mini Organs

May 6, 2016 | Categories: Research | Tagged: , , , ,

Traditionally, gene therapy efforts have attempted to treat genetic diseases by modifying DNA inside a patient’s body, but it has been a challenge to deliver the genetic material to all […] Read More

A mini-kidneyorganoid of 1 mm diameter grown from a patient's stem cells.

Mini-kidney organoids re-create disease in lab dishes

October 23, 2015 | Categories: Research | Tagged: , , , ,

Stem-cell biology and gene editing advances offer hope for kidney regeneration, drug discovery Mini-kidney organoids that re-create human kidney disease have now been grown in laboratory petri dishes. The achievement, […] Read More