Freedman Lab Discovers Promising New Therapeutic for PKD in Tailor-Made Organoids
April 4, 2024 | Categories: Core Faculty, Research |In a new study published in Cell Stem Cell, the Freedman Lab shows that a drug known to be safe in humans inhibits the growth of cysts in gene-edited organoids with polycystic kidney disease. Read More
$7.3 Million NIH Grant Funds Effort to Advance Kidney Microphysiological Testing Platforms
February 12, 2024 | Categories: Core Faculty, Research |NIH Funding will allow ISCRM faculty members Ed Kelly and Beno Freedman to lead the effort to advance kidney-on-a-chip and organoid testing technology and submit a 3D engineered platform for FDA approval. Read More
Research from Freedman Lab Reveals Surprising Finding About Common Cause of Kidney Disease
January 5, 2023 | Categories: Core Faculty, Research |A paper from the Freedman Lab, published this week in Nature Communications, reveals a surprising finding about the way cysts form in PKD organoids, a discovery that could have clinical implications. Read More
Freedman Lab Explores the Role Cilia Play in Signaling, Cell Fate, and Disease Development
April 27, 2022 | Categories: Research |In the Freedman Lab, knocking out primary cilia reveals insights about the role the organelles play in cell fate and disease development. Read More
ISCRM Research Sheds New Light on COVID-19 and Kidney Health
December 2, 2021 | Categories: Core Faculty, Research, Uncategorized |ISCRM researchers use kidney organoids to demonstrate that COVID-19 is capable of infecting kidney cells directly and test whether a synthetic protein designed by the Institute for Protein Design (IPD) might be capable of preventing infection. Read More
With NIH Funding, Freedman Lab to Use Kidney Organoids to Predict Adverse Effects of Genome Editing
October 1, 2019 | Categories: Announcements, Award, Research |Nearly 40 million Americans are impacted by chronic kidney disease, a family of progressive conditions associated with widespread health complications, including higher risk for heart disease. Read More
Robots grow mini-organs from human stem cells
May 17, 2018 | Categories: Research |A robotic approach to mass-producing organoids could accelerate regenerative medicine research and drug discovery. An automated system that uses robots has been designed to rapidly produce human mini-organs derived from stem cells. Researchers at the University of Washington School of Medicine in Seattle developed the new system. Read More
Mini-kidney organoids reveal renal disease secrets
October 2, 2017 | Categories: Research |Kidney organoids are revealing both the factors that influence the formation of kidney cysts, as well as how the disease progresses. The organoids are grown in labware from human stem cells. Polycystic kidney disease affects 12 million people. Until recently, scientists have been unable to recreate the progression of this human disease in a laboratory setting. Read More
New portal vividly reveals the diversity of cell structures
April 5, 2017 | Categories: Announcements |Textbook diagrams of cells show a cursory membrane, nucleus and mitochondria. They have never adequately conveyed cells’ variation and complexity. Seattle’s Allen Institute for Cell Science has unveiled an online portal with stunning […] Read More
With CRISPR, Modeling Disease in Mini Organs
May 6, 2016 | Categories: Research |Traditionally, gene therapy efforts have attempted to treat genetic diseases by modifying DNA inside a patient’s body, but it has been a challenge to deliver the genetic material to all […] Read More