Freedman Lab Discovers Promising New Therapeutic for PKD in Tailor-Made Organoids
April 4, 2024 | Categories: Core Faculty, Research |In a new study published in Cell Stem Cell, the Freedman Lab shows that a drug known to be safe in humans inhibits the growth of cysts in gene-edited organoids with polycystic kidney disease. Read More
Stem Cell-derived Organoids Secrete Tooth Enamel Proteins
August 14, 2023 | Categories: Core Faculty, Research, Uncategorized |Researchers led by Hannele Ruohola-Baker have created organoids from stem cells that secrete the proteins that form the enamel that protects our teeth from damage and decay. Read More
Research from Freedman Lab Reveals Surprising Finding About Common Cause of Kidney Disease
January 5, 2023 | Categories: Core Faculty, Research |A paper from the Freedman Lab, published this week in Nature Communications, reveals a surprising finding about the way cysts form in PKD organoids, a discovery that could have clinical implications. Read More
With NIH Funding, Freedman Lab to Use Kidney Organoids to Predict Adverse Effects of Genome Editing
October 1, 2019 | Categories: Announcements, Award, Research |Nearly 40 million Americans are impacted by chronic kidney disease, a family of progressive conditions associated with widespread health complications, including higher risk for heart disease. Read More
Robots grow mini-organs from human stem cells
May 17, 2018 | Categories: Research |A robotic approach to mass-producing organoids could accelerate regenerative medicine research and drug discovery. An automated system that uses robots has been designed to rapidly produce human mini-organs derived from stem cells. Researchers at the University of Washington School of Medicine in Seattle developed the new system. Read More
Mini-kidney organoids reveal renal disease secrets
October 2, 2017 | Categories: Research |Kidney organoids are revealing both the factors that influence the formation of kidney cysts, as well as how the disease progresses. The organoids are grown in labware from human stem cells. Polycystic kidney disease affects 12 million people. Until recently, scientists have been unable to recreate the progression of this human disease in a laboratory setting. Read More
With CRISPR, Modeling Disease in Mini Organs
May 6, 2016 | Categories: Research |Traditionally, gene therapy efforts have attempted to treat genetic diseases by modifying DNA inside a patient’s body, but it has been a challenge to deliver the genetic material to all […] Read More
Mini-kidney organoids re-create disease in lab dishes
October 23, 2015 | Categories: Research |Stem-cell biology and gene editing advances offer hope for kidney regeneration, drug discovery Mini-kidney organoids that re-create human kidney disease have now been grown in laboratory petri dishes. The achievement, […] Read More