Diagram showing the activation of primary cardiac fibroblasts by TGFβ1, leading to activated fibroblasts. By day 4, fibroblasts are patterned and encapsulated; by day 11, indirect activation occurs via paracrine signaling.

ISCRM Researchers Recover Cells from Hydrogels with Minimal Disturbance

March 1, 2023 | Categories: Uncategorized

Research from the DeForest and Davis Labs describes a new method for cell extraction using engineered versions of an enzyme called sortase that have evolved to recognize and break specific peptide sequences. Read More

Five people stand around a table with drinks, laughing and holding tubing connected to containers, appearing to participate in a fun group activity in an indoor setting.

Science Nights at the Collective

February 21, 2023 | Categories: Uncategorized

Join ISCRM at the Collective in South Lake Union on the evening of May 4 for Cells in Jello: The Wonder of Biomaterials, a free public science talk. Read More

A woman with long brown hair, wearing a dark blazer and maroon top, smiles while standing in a laboratory filled with scientific equipment and glassware.

Meet Jenny Robinson

January 23, 2023 | Categories: Core Faculty

New ISCRM faculty member Jenny Robinson, PhD has built a career researching how differences in sex hormones influence soft tissue regeneration, a question that first occurred to her on the soccer field. Read More

An illustration shows a curved organoid with fluid entering; green cells absorb fluid, causing the organoid to expand and form a cyst, representing cyst growth in polycystic kidney disease (PKD). Arrows indicate the direction of flow and expansion.

Research from Freedman Lab Reveals Surprising Finding About Common Cause of Kidney Disease

January 5, 2023 | Categories: Core Faculty, Research | Tagged: , ,

A paper from the Freedman Lab, published this week in Nature Communications, reveals a surprising finding about the way cysts form in PKD organoids, a discovery that could have clinical implications. Read More

Fluorescent microscopy image of neurons showing glowing cell bodies and branching axons in green, magenta, and red against a dark background, highlighting neural structures and connections.

Ganglion cells created in mice in bid to fix diseased eyes

December 13, 2022 | Categories: Uncategorized

A UW Medicine team led by Tom Reh, PhD had previously shown that neurons could be coaxed from glial cells in the retinal tissue of mice. Now they’ve refined the process to produce specific cells. Read More

A simplified cartoon diagram of a mitochondrion, showing a green outer membrane and a red, folded inner membrane structure inside.

Another Job for Mighty Mitochondria: Regulating Stem Cell Division

December 8, 2022 | Categories: Uncategorized

Research from the Ruohola-Baker Lab shows that mitochondria determine whether a stem cell can reproduce or not, a finding that sheds new light on the factors that influence cell cycles. Read More

Two translucent fish are shown side by side against a white background, revealing skeletal structures and internal organs with faint details visible through their bodies.

ISCRM Researchers Identify Gene With Dual Influence on Bone and Muscle Development

November 29, 2022 | Categories: Core Faculty, Research | Tagged: , , , , ,

Using zebrafish as a model, researchers from the Musculoskeletal Systems Biology Lab describe how wnt16 dually influences bone and muscle development and growth. Read More

Two women smiling outdoors. The woman on the left has curly hair and wears a white blouse; the woman on the right has straight, dark hair and wears a gray blazer over a black top. Greenery is visible in the blurred backgrounds.

WRF Fellowships for Two ISCRM Undergraduate Researchers

November 7, 2022 | Categories: Award, Core Faculty, Heart Regeneration | Tagged: , , ,

Undergraduate student researchers Dessirée Ortaç and Eesha Murali have received Washington Research Foundation Fellowships that will support their time in the lab through the end of the 2023 school year. Read More

A collage with three men posing for portraits in separate squares and an illustration of a DNA double helix with a neuron at the top right in the fourth square.

Special Issue in Frontiers in Cell and Developmental Biology Edited by David Mack, Mark Bothwell, and Alec Smith

October 14, 2022 | Categories: Uncategorized

David Mack, Mark Bothwell, and Alec Smith are the editors of a special issue of Frontiers in Cell & Developmental Biology that explores different models for investigating neuromuscular disease and weighing the pros and cons of stem cell-based models versus cell lines and animal models. Read More

Aerial view of downtown Seattle with the Space Needle and surrounding buildings at dusk; CASCADIA 4.0 is written in bold white letters across the bottom left of the image.

Cascadia Corridor Research Symposium Comes to Seattle

October 10, 2022 | Categories: Announcements, Core Faculty, Research | Tagged:

The symposium will take place November 3-4 on the UW Medicine South Lake Union campus and will feature keynote addresses from ISCRM Associate Director Jen Davis, PhD and David Granville, PhD, Professor and Associate Dean Research, Faculty of Medicine, University of British Columbia. Read More