Yang Lab Co-Leads NIH-Funded Effort to Improve Genetic Testing for HCM
November 4, 2024 | Categories: Research |An NIH-funded partnership between ISCRM faculty member Dr. Daniel Yang and Dr. Lea Starita in the UW Department of Genome Sciences will use an innovative gene editing technology to sequence large numbers of variants of a mutation associated with hypertrophic cardiomyopathy. Read More about Yang Lab Co-Leads NIH-Funded Effort to Improve Genetic Testing for HCM
Freedman Lab Discovers Promising New Therapeutic for PKD in Tailor-Made Organoids
April 4, 2024 | Categories: Core Faculty, Research |In a new study published in Cell Stem Cell, the Freedman Lab shows that a drug known to be safe in humans inhibits the growth of cysts in gene-edited organoids with polycystic kidney disease. Read More about Freedman Lab Discovers Promising New Therapeutic for PKD in Tailor-Made Organoids
Grant for Escobar Lab Funds AML Research
July 13, 2022 | Categories: Award, Core Faculty, Research |Thelma Escobar, PhD is collaborating with the Doulatov Lab and the Stem Cell Core to study how mutations in the gene NPM1 drive AML onset. Read More about Grant for Escobar Lab Funds AML Research
Young Lab Links Loss of SORL1 Gene to Increased Alzheimer’s Risk
June 2, 2020 | Categories: Research |To overcome the inherent challenges in studying the brain, one ISCRM team used stem cell technology to implicate a gene known as SORL1 in some types of Alzheimer’s and to shed new light on why many promising treatments for this disease have hit dead ends in clinical trials. Read More about Young Lab Links Loss of SORL1 Gene to Increased Alzheimer’s Risk
With NIH Funding, Freedman Lab to Use Kidney Organoids to Predict Adverse Effects of Genome Editing
October 1, 2019 | Categories: Announcements, Award, Research |Nearly 40 million Americans are impacted by chronic kidney disease, a family of progressive conditions associated with widespread health complications, including higher risk for heart disease. Read More about With NIH Funding, Freedman Lab to Use Kidney Organoids to Predict Adverse Effects of Genome Editing
With CRISPR, Modeling Disease in Mini Organs
May 6, 2016 | Categories: Research |Traditionally, gene therapy efforts have attempted to treat genetic diseases by modifying DNA inside a patient’s body, but it has been a challenge to deliver the genetic material to all […] Read More about With CRISPR, Modeling Disease in Mini Organs