Drug treatments can save lives, but sometimes they also carry unintended costs. After all, the same therapeutics that target pathogens and tumors can also harm healthy cells. To reduce this collateral damage, scientists have long sought specificity in drug delivery systems: A package that can encase a therapeutic and will not disgorge its toxic cargo until it reaches the site of treatment — be it a tumor, a diseased organ or a site of infection. Read More
Researchers built an algorithm to discern which drugs might best combat patients’ individual cases of acute myeloid leukemia. The statistics are grim. For patients fighting an aggressive form of leukemia known as acute myeloid leukemia, or AML, doctors over the last 40 years have usually used a combination of two drugs to fight the disease, but it seldom cures it. Read More
A therapy developed at UW shows promise in its first test in young boys who have an inherited deadly muscle disease. Favorable interim results have been announced in a small clinical trial of a stem-cell therapy to treat patients with a rare, deadly disease called myotubular myopathy. Read More
Congratulations to the 2017 ISCRM Scholars and Innovation Pilot Program Awardees The ISCRM Scholars Program, funded by the State of Washington, is a newly established program that provides one year […] Read More
Researchers are reporting significant progress in generating a 3-dimensional network of blood vessels that can be grown and manipulated in a laboratory. Building vascular support for stem-cell repaired tissues or replacement organs will be vital to such regenerative therapies. Read More
Kidney organoids are revealing both the factors that influence the formation of kidney cysts, as well as how the disease progresses. The organoids are grown in labware from human stem cells. Polycystic kidney disease affects 12 million people. Until recently, scientists have been unable to recreate the progression of this human disease in a laboratory setting. Read More
Beginning four years ago, 15 women with incurable (metastatic triple-negative) breast cancer were enrolled in a unique clinical trial. It explored one concept of “precision medicine” – the suggestion that the brain power of multiple medical experts and the collection of an immense volume of data about each woman’s condition would yield the most personalized, customized care possible. Read More
The Institute for Stem Cell and Regenerative Medicine (ISCRM) is pleased to announce the 2017 winners of the Tietze Research Awards in Stem Cell Research, funded through a generous multi-year commitment by the John H. Tietze Foundation. Read More
UW Medicine researchers recently lead a successful effort to create “designer” stem cells that might lead to advances in cancer and aging, they say. In a paper published in the journal PNAS, the scientists showed for the first time that a computer-generated protein can be inserted into stem cells to change their epigenetic memory, whose role is to ensure that a cell’s DNA sequence remains intact as it divides. Read More
ISCRM is pleased to announce its new Innovation Pilot Award (IPA) program. Supported by new resources from the State of Washington, the IPA program aims to support innovative research of […] Read More
Chuck Murry, MD, PhD Professor of Laboratory Medicine & Pathology, Bioengineering and Medicine/Cardiology "You are What You Eat: Using Metabolism to Drive hPSC-Cardiomyocyte Maturation" Ian Jan Graduate Student in Allbritton […]
Olivia Bermingham-McDonogh, PhD Professor of Biological Structure "Ebf1 in cochlear sensory development" Nick Petty GTRM Student from the Kiem Lab "Engraftment of cells to the central nervous system following hematopoietic […]
Shelly Sakiyama-Elbert, PhD Professor of Bioengineering Title TBD Fan Zhang, PhD Postdoctoral Scholar in Stevens lab "High-throughput in vivo screening of biomaterials for regenerative medicine"
