Stem Cell-derived Organoids Secrete Tooth Enamel Proteins
August 14, 2023 | Categories: Core Faculty, Research, Uncategorized |Researchers led by Hannele Ruohola-Baker have created organoids from stem cells that secrete the proteins that form the enamel that protects our teeth from damage and decay. Read More
Regulating Cells With Designed Proteins
March 1, 2022 | Categories: Core Faculty, Research |ISCRM researchers have developed a tool to selectively control the PRC2 complex – an epigenetic regulator that influences cell fate across multiple stages of development. That tool is a computer-designed protein binder engineered in partnership with the Institute for Protein Design (IPD). Read More
Priming the Heart for Regeneration
January 10, 2022 | Categories: Research |In 2015, a team of inquisitive young scientists, absorbed in the study of metabolism, regeneration, and biological development, set out to answer a question. Could the way cells produce energy help explain why certain organisms have an envious ability to regenerate heart tissue after injury? And, if so, could that knowledge be used to help heal human hearts? Read More
ISCRM Research Sheds New Light on COVID-19 and Kidney Health
December 2, 2021 | Categories: Core Faculty, Research, Uncategorized |ISCRM researchers use kidney organoids to demonstrate that COVID-19 is capable of infecting kidney cells directly and test whether a synthetic protein designed by the Institute for Protein Design (IPD) might be capable of preventing infection. Read More
Undergraduate Students on the Hunt for Cancer Killing Molecules
November 3, 2021 | Categories: Core Faculty |Described in the journal Cells, a multi-year effort to identify molecules that target cancer cells gave UW undergraduates real-world laboratory experience. Read More
New Investigator Award for Julie Mathieu Funds Collaborative Cancer Research
June 11, 2021 | Categories: Award, Research |Fueled in part by a New Investigator Award from the Cancer Consortium, ISCRM faculty member Julie Mathieu, PhD is partnering with scientists at the Institute for Protein Design and Fred Hutch to develop new treatments for renal cell carcinoma. Read More
Supercharging Antibodies for Better Medicine
April 2, 2021 | Categories: Uncategorized |Researchers from the Ruohola-Baker Lab have collaborated with the Institute for Protein Design on a technology in which designed proteins assemble antibodies in nanocage structures, increasing their potency against cancer, COVID-19, and other diseases. Read More
Insights on Genetic Causes of SIDS-linked Disease Published in Nature Communications
October 14, 2019 | Categories: Research |Each year, according to the CDC, approximately 3,600 infant deaths in the United States are attributed to Sudden Unexplained Infant Death Syndrome (SUIDS) – an umbrella category that includes Sudden Infant Death Syndrome (SIDS). Read More
ISCRM and the UW School of Dentistry Reveal New Findings About the Nature of Stem Cells in Human Teeth
February 22, 2019 | Categories: Research |Long before Hannele Ruohola-Baker became a leading stem cell researcher, she was a young hockey player skating on the frozen ponds of her native Finland. When she was ten years old, she lost a tooth to an errant puck. “I’d say that’s when my interest in regenerating teeth began,” says Dr. Ruohola-Baker, now a Professor of Biochemistry and Associate Director of the UW Medicine Institute for Stem Cell and Regenerative Medicine (ISCRM). Read More