A person with red hair gestures while sitting in front of a computer displaying a colorful 3D model. A whiteboard with diagrams is in the background, and purple graphics border the image on the right.

Study Yields New Clue to Strokes of Undetermined Source

May 4, 2021 | Categories: Core Faculty, Research, Uncategorized | Tagged: , ,

Simulations shed light on heart-scarring similarities among patients with atrial fibrillation and those who had embolic stroke but no atrial fibrillation. Read More

Rainbow Heart

ISCRM Researchers Use Rainbow Reporters to Examine Proliferation of Engrafted Heart Cells

April 19, 2021 | Categories: Core Faculty, Heart Regeneration, Research, Uncategorized | Tagged: , , , ,

ISCRM investigators use rainbow cell technology to demonstrate that injected heart cells proliferate, a finding that could help researchers enhance the efficacy of cell therapy for heart disease and other conditions. Read More

Cover of Advanced Healthcare Materials featuring a stylized illustration of blood vessels in red and blue with cell nuclei in purple, and diagrams of glomeruli above, showing a process or transformation with arrows.

Engineering Microvasculature in Full 3D Complexity

March 4, 2021 | Categories: Core Faculty, Research | Tagged: , , ,

ISCRM researchers led by Ying Zheng, PhD, detail a method to generate microvaculature in full 3D complexity using multiphoton ablation and laser-guided cellularization Read More

A four-panel figure showing fluorescent microscopy images of microfabricated structures: (a) a 3D bar graph, (b) multiple grid patterns, (c) a horizontal grid, and (d) a tree-like branching pattern, all with scale bars.

DeForest Lab Pioneers 4D Biomimicry Systems With Ingenuity, Collaboration, and an NIH Grant

October 1, 2020 | Categories: Award, Core Faculty, Uncategorized | Tagged: , ,

In reality show terms, Cole DeForest and his team manufacture tiny bio-worlds staged to mimic living systems, force an eclectic cast of cells to cohabitate, apply light, heat, and chemicals to stir up drama, then record it all with sophisticated monitoring equipment. What they see on the tiniest scales, could have major implications for medicine. Read More

The cover of iScience magazine features a microscopic image of cells in vibrant colors—green, red, blue, and purple—forming circular and clustered patterns. Yellow text displays the magazines title and publication details.

Improved Method for Converting Stem Cells into Pancreatic Islet Progenitor Cells Detailed in iScience

August 29, 2019 | Categories: Announcements, Core Faculty, Research | Tagged: , , , , ,

Type 1 diabetes is a disease that occurs when the immune system attacks and kills the cells that produce insulin in the pancreas, known as beta-cells. Read More

Fluorescent microscopy image showing elongated muscle fibers with green and red staining, and blue oval nuclei scattered throughout. A white scale bar indicates 50 micrometers at the bottom right.

ISCRM Researchers to Play Pivotal Roles on NIH-Funded Collaboration with Stanford

July 10, 2019 | Categories: Announcements, Award, Core Faculty | Tagged: , , , , , ,

Over the last decade, human induced pluripotent stem cells (iPSCs) have become powerful tools of discovery for scientists around the world. Read More

Side-by-side grayscale images labeled ATP and dATP, each showing a central bright spot with symmetrical red and black patterns radiating outward, likely representing X-ray diffraction results.

New Findings About dATP-Enhanced Heart Contractions Published in PNAS

May 21, 2019 | Categories: Core Faculty, Research | Tagged: , , , , ,

Heart failure is a widespread chronic condition that directly impacts nearly six million Americans, contributes to almost one in ten deaths in the United States, and drains an estimated $30 billion annually from our national economy. Read More

A close-up of a red, net-like 3D-printed structure, resembling a small sac or lung, suspended in a yellowish liquid within a transparent container.

Breakthroughs in 3D Organ Printing Detailed in Science

May 2, 2019 | Categories: Core Faculty, Research | Tagged: , , ,

Bioengineers have cleared a major hurdle on the path to 3D printing replacement organs with a breakthrough technique for bioprinting tissues. The new innovation allows scientists to create exquisitely entangled vascular networks that mimic the body's natural passageways for blood, air, lymph and other vital fluids. Read More

Four immunofluorescence microscopy images showing tissue stained with markers: red (Nkx3.1 or K5), green (Ror2), and blue (nuclei/DAPI). Each panel highlights different staining patterns and structures.

Studying Cell Signaling in the Prostate

April 15, 2019 | Categories: Core Faculty, Research | Tagged: , , ,

While prostate cancer may not be as deadly as other cancers – five-year survival rates can exceed 90%, especially if the disease is localized – incidence rates overall are increasing. For 2019 alone, The American Cancer Society predicts the United States will see roughly 175,000 new cases and 32,000 deaths associated with prostate cancer. Read More