ISCRM Researchers Use AI-Designed Protein to Produce More Mineralized Enamel
March 2, 2026 | Categories: Core Faculty, Research |ISCRM researchers have shown that an AI-designed signaling protein (known as a ligand) can be used to mature ameloblasts capable of secreting more mineralized enamel, representing another important step forward for regenerative dentistry. Read More about ISCRM Researchers Use AI-Designed Protein to Produce More Mineralized Enamel
Harnessing Early Progenitors to Grow Healthy Kidney Tissue Inside the Body
February 18, 2026 | Categories: Research |The Freedman Lab used a single pool of stem cells to generate multiple cell types crucial for kidney function and showed it may be more effective to kickstart this process in vivo instead of engineering tissue outside the body for transplantation. Read More about Harnessing Early Progenitors to Grow Healthy Kidney Tissue Inside the Body
Freedman Lab Tests a Promising mTOR Inhibitor in PKD Organoids
January 23, 2025 | Categories: Research |The study results suggest the molecule at the center of the study may be safer at higher doses and therefore more potent against harmful cysts. Read More about Freedman Lab Tests a Promising mTOR Inhibitor in PKD Organoids
Freedman Lab Discovers Promising New Therapeutic for PKD in Tailor-Made Organoids
April 4, 2024 | Categories: Core Faculty, Research |In a new study published in Cell Stem Cell, the Freedman Lab shows that a drug known to be safe in humans inhibits the growth of cysts in gene-edited organoids with polycystic kidney disease. Read More about Freedman Lab Discovers Promising New Therapeutic for PKD in Tailor-Made Organoids
$7.3 Million NIH Grant Funds Effort to Advance Kidney Microphysiological Testing Platforms
February 12, 2024 | Categories: Core Faculty, Research |NIH Funding will allow ISCRM faculty members Ed Kelly and Beno Freedman to lead the effort to advance kidney-on-a-chip and organoid testing technology and submit a 3D engineered platform for FDA approval. Read More about $7.3 Million NIH Grant Funds Effort to Advance Kidney Microphysiological Testing Platforms
Research from Freedman Lab Reveals Surprising Finding About Common Cause of Kidney Disease
January 5, 2023 | Categories: Core Faculty, Research |A paper from the Freedman Lab, published this week in Nature Communications, reveals a surprising finding about the way cysts form in PKD organoids, a discovery that could have clinical implications. Read More about Research from Freedman Lab Reveals Surprising Finding About Common Cause of Kidney Disease
Freedman Lab Explores the Role Cilia Play in Signaling, Cell Fate, and Disease Development
April 27, 2022 | Categories: Research |In the Freedman Lab, knocking out primary cilia reveals insights about the role the organelles play in cell fate and disease development. Read More about Freedman Lab Explores the Role Cilia Play in Signaling, Cell Fate, and Disease Development
ISCRM Research Sheds New Light on COVID-19 and Kidney Health
December 2, 2021 | Categories: Core Faculty, Research, Uncategorized |ISCRM researchers use kidney organoids to demonstrate that COVID-19 is capable of infecting kidney cells directly and test whether a synthetic protein designed by the Institute for Protein Design (IPD) might be capable of preventing infection. Read More about ISCRM Research Sheds New Light on COVID-19 and Kidney Health
With NIH Funding, Freedman Lab to Use Kidney Organoids to Predict Adverse Effects of Genome Editing
October 1, 2019 | Categories: Announcements, Award, Research |Nearly 40 million Americans are impacted by chronic kidney disease, a family of progressive conditions associated with widespread health complications, including higher risk for heart disease. Read More about With NIH Funding, Freedman Lab to Use Kidney Organoids to Predict Adverse Effects of Genome Editing
Robots grow mini-organs from human stem cells
May 17, 2018 | Categories: Research |A robotic approach to mass-producing organoids could accelerate regenerative medicine research and drug discovery. An automated system that uses robots has been designed to rapidly produce human mini-organs derived from stem cells. Researchers at the University of Washington School of Medicine in Seattle developed the new system. Read More about Robots grow mini-organs from human stem cells