Freedman Lab Explores the Role Cilia Play in Signaling, Cell Fate, and Disease Development
April 27, 2022 | Categories: Research |In the Freedman Lab, knocking out primary cilia reveals insights about the role the organelles play in cell fate and disease development. Read More
Deletion of Lamin B1 Linked to Nuclear Abnormalities Seen in Cancer
March 11, 2022 | Categories: Research, Uncategorized |Using gene-editing tools to decrease expression of lamin B1 in two stem cell models, the researchers show that deletion of lamin B1 causes change in stem cell function and nuclear shape – and contributes to leukemia progression. Read More
Regulating Cells With Designed Proteins
March 1, 2022 | Categories: Core Faculty, Research |ISCRM researchers have developed a tool to selectively control the PRC2 complex – an epigenetic regulator that influences cell fate across multiple stages of development. That tool is a computer-designed protein binder engineered in partnership with the Institute for Protein Design (IPD). Read More
Davis Lab Examines a Protein With a Key Role in Scarring
February 16, 2022 | Categories: Core Faculty, Research |In a study that came with some unexpected findings, ISCRM researchers reveal new details about the role an RNA binding protein (MBNL1) plays in the steps that lead to scarring in the heart. Read More
Kelly Stevens receives $1.3M Allen Distinguished Investigator Award to study how liver develops
February 9, 2022 | Categories: Award, Core Faculty, Research |Kelly Stevens has received an Allen Distinguished Investigator Award to support her work to map and understand how human livers develop. Read More
Priming the Heart for Regeneration
January 10, 2022 | Categories: Research |In 2015, a team of inquisitive young scientists, absorbed in the study of metabolism, regeneration, and biological development, set out to answer a question. Could the way cells produce energy help explain why certain organisms have an envious ability to regenerate heart tissue after injury? And, if so, could that knowledge be used to help heal human hearts? Read More
ISCRM Research Sheds New Light on COVID-19 and Kidney Health
December 2, 2021 | Categories: Core Faculty, Research, Uncategorized |ISCRM researchers use kidney organoids to demonstrate that COVID-19 is capable of infecting kidney cells directly and test whether a synthetic protein designed by the Institute for Protein Design (IPD) might be capable of preventing infection. Read More
Nudging Cells to Repair Damaged Retinas
October 25, 2021 | Categories: Core Faculty, Research |Researchers led by ISCRM faculty member Tom Reh induce support cells in the retina to become neurons, an approach that someday could help restore vision. Read More
Watch a Brief Video About ISCRM
September 17, 2021 | Categories: Core Faculty, ResearchWatch this brief video about the collaborative research community harnessing advances in biology and engineering to confront the root causes of disease. Read More
Kelly Stevens, Jay Shendure, and Cole Trapnell Detail Spatial-Mapping Technology
July 2, 2021 | Categories: Core Faculty, Research |UW researchers have created a technique to build single-cell resolution spatial maps of the molecular profiles of mammal cell types Read More