Modeling a Muscle Disease in 3D
August 17, 2022 | Categories: Award, Core Faculty, Research, Uncategorized |A team of investigators led by ISCRM faculty members David Mack, PhD and Nate Sniadecki, PhD have shown that is possible to recreate DMD with much more complexity in a 3D model of engineered heart tissue. Read More
Meet the 2022-2023 ISCRM Fellows
August 1, 2022 | Categories: Award, Research, Uncategorized |State-funded ISCRM Fellowships enable students at the undergraduate, graduate, and postdoctoral level to advance research efforts aimed at addressing the root causes of diseases. Read More
Grant for Escobar Lab Funds AML Research
July 13, 2022 | Categories: Award, Core Faculty, Research |Thelma Escobar, PhD is collaborating with the Doulatov Lab and the Stem Cell Core to study how mutations in the gene NPM1 drive AML onset. Read More
Boyle Lab Leads Effort to Improve Stroke Risk Assessment
July 5, 2022 | Categories: Award, Core Faculty, Research |ISCRM faculty member Patrick Boyle has received a five-year, $2.9 million grant from the National Heart, Lung, and Blood Institute to improve outcomes for stroke patients by identifying and testing individualized strategies for diagnosing and treating strokes. Read More
Freedman Lab Explores the Role Cilia Play in Signaling, Cell Fate, and Disease Development
April 27, 2022 | Categories: Research |In the Freedman Lab, knocking out primary cilia reveals insights about the role the organelles play in cell fate and disease development. Read More
Deletion of Lamin B1 Linked to Nuclear Abnormalities Seen in Cancer
March 11, 2022 | Categories: Research, Uncategorized |Using gene-editing tools to decrease expression of lamin B1 in two stem cell models, the researchers show that deletion of lamin B1 causes change in stem cell function and nuclear shape – and contributes to leukemia progression. Read More
Regulating Cells With Designed Proteins
March 1, 2022 | Categories: Core Faculty, Research |ISCRM researchers have developed a tool to selectively control the PRC2 complex – an epigenetic regulator that influences cell fate across multiple stages of development. That tool is a computer-designed protein binder engineered in partnership with the Institute for Protein Design (IPD). Read More
Davis Lab Examines a Protein With a Key Role in Scarring
February 16, 2022 | Categories: Core Faculty, Research |In a study that came with some unexpected findings, ISCRM researchers reveal new details about the role an RNA binding protein (MBNL1) plays in the steps that lead to scarring in the heart. Read More
Kelly Stevens receives $1.3M Allen Distinguished Investigator Award to study how liver develops
February 9, 2022 | Categories: Award, Core Faculty, Research |Kelly Stevens has received an Allen Distinguished Investigator Award to support her work to map and understand how human livers develop. Read More
Priming the Heart for Regeneration
January 10, 2022 | Categories: Research |In 2015, a team of inquisitive young scientists, absorbed in the study of metabolism, regeneration, and biological development, set out to answer a question. Could the way cells produce energy help explain why certain organisms have an envious ability to regenerate heart tissue after injury? And, if so, could that knowledge be used to help heal human hearts? Read More