Rainbow Heart

ISCRM Researchers Use Rainbow Reporters to Examine Proliferation of Engrafted Heart Cells

April 19, 2021 | Categories: Core Faculty, Heart Regeneration, Research, Uncategorized | Tagged: , , , ,

ISCRM investigators use rainbow cell technology to demonstrate that injected heart cells proliferate, a finding that could help researchers enhance the efficacy of cell therapy for heart disease and other conditions. Read More

Cover of Advanced Healthcare Materials featuring a stylized illustration of blood vessels in red and blue with cell nuclei in purple, and diagrams of glomeruli above, showing a process or transformation with arrows.

Engineering Microvasculature in Full 3D Complexity

March 4, 2021 | Categories: Core Faculty, Research | Tagged: , , ,

ISCRM researchers led by Ying Zheng, PhD, detail a method to generate microvaculature in full 3D complexity using multiphoton ablation and laser-guided cellularization Read More

Fluorescent microscopy image of an oval-shaped muscle cell, with pink and green lines showing the organized structure of muscle fibers and connective tissues against a black background.

ISCRM Researchers Pursue Personalized Medicine for Heart Failure

December 3, 2020 | Categories: Award, Research | Tagged: , , , ,

With a Collaborative Science Award from the American Heart Association Jen Davis, Farid Moussavi-Harami , and Tom Daniel are on a mission to develop new tools to help cardiologists personalize treatments for certain heart diseases too. Read More

Side-by-side images: on the left, a translucent blue object with geometric shapes; on the right, a heat map with bright yellow, orange, and red colors centered within cooler blue and black edges.

Stevens Lab Unveils Novel System for Regulating Gene Expression with Heat

September 30, 2020 | Categories: Research, Uncategorized | Tagged: , , , ,

Researchers hoping to create disease models or regenerate organs need systems that precisely mimic the degree of complexity found in the natural world. The Stevens Lab is helping to answer the call with a new system that regulates gene expression patterns using heat Read More

A glowing, glittery ring with purple and green specks floats against a black background, forming a smooth, continuous circular shape.

Zheng Lab Uses New 3D Model to Study Effect of Curvature on Endothelial Cells

September 16, 2020 | Categories: Research | Tagged: , , ,

Every day, million of cars navigate a complex network of wide, straight highways, busy streets and avenues, and side roads that bend and curve in unpredictable patterns. Now a new 3D modeling tool will help scientists study even more complex traffic patterns at work in our blood vessels. Read More

Fluorescence microscopy image of cells with irregular, interconnected shapes outlined in green, red, and blue, against a dark background, highlighting the cellular membrane structures.

Color-Coding Technology Reveals New Insights About Stem Cell Biology

July 29, 2020 | Categories: Research | Tagged: , , ,

Several years ago, Danny El-Nachef was given a mission to create a tool to observe and track how stem cells behaved during the earliest stages of human heart development. While the focus of the challenge was human biology, the x-factor in the solution came from the sea. Read More

Fluorescent microscopy image showing branching red structures, green spots, and blue oval shapes, likely representing stained cells with visible nuclei. Black background highlights the cell structures.

Young Lab Links Loss of SORL1 Gene to Increased Alzheimer’s Risk

June 2, 2020 | Categories: Research | Tagged: , , ,

To overcome the inherent challenges in studying the brain, one ISCRM team used stem cell technology to implicate a gene known as SORL1 in some types of Alzheimer’s and to shed new light on why many promising treatments for this disease have hit dead ends in clinical trials. Read More