In an exciting breakthrough that may have implications for stem cell-based treatment of heart disease, the lab of Dr. Deok-Ho Kim at the Institute for Stem Cell and Regenerative Medicine […] Read More
Drug response screening of leukemia stem cells offers clues to relapse and suggests ways to improve patient-specific therapies Advances in rapid screening of leukemia cells for drug susceptibility and resistance […] Read More
Collaboration is the engine of scientific progress at UW Medicine and at the Institute of Stem Cell & Regenerative Medicine (ISCRM), where 130 researchers are developing stem cell-based approaches to treat diseases affecting nearly every organ and system in the human body. Read More
Acute lymphocytic leukemia (ALL) is the most common type of childhood cancer, representing approximately 25% of cancer diagnoses in children 0-15. More than 3,000 new cases of ALL are diagnosed every year in the United States - and the incidence rate is rising. Read More
Results of a study published today in Nature Biotechnology suggest techniques that could treat patients with heart failure. Researchers at UW Medicine in Seattle have successfully used human stem cells to restore heart function in monkeys with heart failure. The findings suggest that the technique will be effective in patients with heart failure, the leading cause of death in the world. Read More
New cell lines will allow researchers to probe the basic biology of Alzheimer’s. Currently, however, there are no treatments that can prevent or slow the progression of this memory-robbing disease, which affects more than 5 million Americans. One reason for this is that we really don’t know the cause of Alzheimer’s: It is known that brain cells that are crucial to forming new memories die. But we don’t know why. Read More
On May 9, 2018, three new ISCRM human embryonic stem cell (hESC) lines were accepted onto the NIH Stem Cell Registry. Originated from donated human preimplantation blastocysts, Carol Ware derived […] Read More
A robotic approach to mass-producing organoids could accelerate regenerative medicine research and drug discovery. An automated system that uses robots has been designed to rapidly produce human mini-organs derived from stem cells. Researchers at the University of Washington School of Medicine in Seattle developed the new system. Read More
Improving the trafficking of cellular proteins in brain cells holds possibilities for new treatments and even prevention for Alzheimer’s disease, results of a new study suggest. Researchers found that a compound that enhances the shuttling of proteins within cells reduced the production of forerunners of two proteins implicated in brain cell death. Read More
Drug treatments can save lives, but sometimes they also carry unintended costs. After all, the same therapeutics that target pathogens and tumors can also harm healthy cells. To reduce this collateral damage, scientists have long sought specificity in drug delivery systems: A package that can encase a therapeutic and will not disgorge its toxic cargo until it reaches the site of treatment — be it a tumor, a diseased organ or a site of infection. Read More