A close-up of a red, net-like 3D-printed structure, resembling a small sac or lung, suspended in a yellowish liquid within a transparent container.

Breakthroughs in 3D Organ Printing Detailed in Science

May 2, 2019 | Categories: Core Faculty, Research | Tagged: , , ,

Bioengineers have cleared a major hurdle on the path to 3D printing replacement organs with a breakthrough technique for bioprinting tissues. The new innovation allows scientists to create exquisitely entangled vascular networks that mimic the body's natural passageways for blood, air, lymph and other vital fluids. Read More

Four immunofluorescence microscopy images showing tissue stained with markers: red (Nkx3.1 or K5), green (Ror2), and blue (nuclei/DAPI). Each panel highlights different staining patterns and structures.

Studying Cell Signaling in the Prostate

April 15, 2019 | Categories: Core Faculty, Research | Tagged: , , ,

While prostate cancer may not be as deadly as other cancers – five-year survival rates can exceed 90%, especially if the disease is localized – incidence rates overall are increasing. For 2019 alone, The American Cancer Society predicts the United States will see roughly 175,000 new cases and 32,000 deaths associated with prostate cancer. Read More

Fluorescent microscopy image of cells with blue-stained nuclei (DAPI), red-stained cytoskeleton (Phalloidin), and green-stained Barx1. Scale bar indicates 50 μm. Text DPSC 29 in lower left corner.

ISCRM and the UW School of Dentistry Reveal New Findings About the Nature of Stem Cells in Human Teeth

February 22, 2019 | Categories: Research | Tagged: , , ,

Long before Hannele Ruohola-Baker became a leading stem cell researcher, she was a young hockey player skating on the frozen ponds of her native Finland. When she was ten years old, she lost a tooth to an errant puck. “I’d say that’s when my interest in regenerating teeth began,” says Dr. Ruohola-Baker, now a Professor of Biochemistry and Associate Director of the UW Medicine Institute for Stem Cell and Regenerative Medicine (ISCRM). Read More

A grid of sixteen fluorescent microscopy images showing cell nuclei in various colors—magenta, green, blue, and merged combinations—highlighting different stains and cellular features.

Aided by Stem Cells, ISCRM Researchers Identify a Suspect in the Case of Infertility

February 7, 2019 | Categories: Core Faculty, Research | Tagged: ,

February 7, 2019 Of all the mysteries surrounding the beginning of human life, one question has drawn particular interest from researchers at the Institute for Stem Cell and Regenerative Medicine […] Read More

Fluorescent microscopic image showing a grid pattern outlined in bright pink, with green and blue speckles in the background. The grid is composed of nine squares, and a white scale bar appears in the lower right corner.

ISCRM Labs Collaborate to Grow Heart Tissue In Vitro

February 4, 2019 | Categories: Research | Tagged: , , ,

February 4, 2019 Heart failure is the leading cause of death in the world. In the United States alone, hundreds of thousands of people succumb to the disease every year, […] Read More

Three microscopic images of mouse heart muscle tissue, labeled a, b, and c, with text describing the results of micro-dystrophin gene therapy for Duchenne muscular dystrophy. Images show green-stained muscle fibers with varying patterns.

Gene Therapy Cassettes Improved for Muscular Dystrophy

February 1, 2019 | Categories: Research | Tagged: , , ,

February 1, 2019 Experimental gene therapy cassettes for Duchenne muscular dystrophy have been modified to deliver better performance.  The cassettes, which carry the therapy into muscle cells, contain newer versions […] Read More

Two people are shown side by side in portrait photos. The person on the left has long dark hair and is smiling, wearing a light-colored top. The person on the right has short dark hair, is also smiling, and wears a dark shirt.

Tietze Young Scientist Awards for Two ISCRM Faculty Members

January 31, 2019 | Categories: Award, Research

Two ISCRM faculty members, Dr. Smita Yadav, Assistant Professor, Pharmacology and Dr. Ronald Kwon, Associate Professor, Orthopedics and Sports Medicine, have received prestigious awards from the John H. Tietze Foundation […] Read More

Cover of the Journal of Materials Chemistry B, featuring an artistic illustration of orange and blue elliptical cells on a ribbed white surface, with journal details and themed issue information displayed.

Enhancing the Development of Heart Cells Using Materials Derived From Silk

December 17, 2018 | Categories: Announcements, Core Faculty, Heart Regeneration, Research

In an exciting breakthrough that may have implications for stem cell-based treatment of heart disease, the lab of Dr. Deok-Ho Kim at the Institute for Stem Cell and Regenerative Medicine […] Read More

Panel A shows a scatter plot of compounds by sensitivity in AML blasts and LSCs, with blast-specific, LSC-specific, and non-specific drugs colored. Panel B shows a heatmap of inhibition by AML blast-specific compounds in AML blasts and LSCs.

Potential Seen for Tailoring Acute Myeloid Leukemia Treatment

December 3, 2018 | Categories: Announcements, Research | Tagged: , ,

Drug response screening of leukemia stem cells offers clues to relapse and suggests ways to improve patient-specific therapies Advances in rapid screening of leukemia cells for drug susceptibility and resistance […] Read More

Fluorescent microscopy image showing green-stained fibrous cell structures and red-stained round regions, likely representing cell nuclei and other components, against a black background.

ISCRM Faculty Shine a New Light on Scarring

October 12, 2018 | Categories: Research | Tagged: , , ,

Collaboration is the engine of scientific progress at UW Medicine and at the Institute of Stem Cell & Regenerative Medicine (ISCRM), where 130 researchers are developing stem cell-based approaches to treat diseases affecting nearly every organ and system in the human body.   Read More