Ganglion cells created in mice in bid to fix diseased eyes

December 13, 2022 | Categories: Uncategorized

A UW Medicine team led by Tom Reh, PhD had previously shown that neurons could be coaxed from glial cells in the retinal tissue of mice. Now they’ve refined the process to produce specific cells. Read More

Another Job for Mighty Mitochondria: Regulating Stem Cell Division

December 8, 2022 | Categories: Uncategorized

Research from the Ruohola-Baker Lab shows that mitochondria determine whether a stem cell can reproduce or not, a finding that sheds new light on the factors that influence cell cycles. Read More

Special Issue in Frontiers in Cell and Developmental Biology Edited by David Mack, Mark Bothwell, and Alec Smith

October 14, 2022 | Categories: Uncategorized

David Mack, Mark Bothwell, and Alec Smith are the editors of a special issue of Frontiers in Cell & Developmental Biology that explores different models for investigating neuromuscular disease and weighing the pros and cons of stem cell-based models versus cell lines and animal models. Read More

Modeling a Muscle Disease in 3D

August 17, 2022 | Categories: Award, Core Faculty, Research, Uncategorized | Tagged: , ,

A team of investigators led by ISCRM faculty members David Mack, PhD and Nate Sniadecki, PhD have shown that is possible to recreate DMD with much more complexity in a 3D model of engineered heart tissue. Read More

Group of people standing outside

Meet the 2022-2023 ISCRM Fellows

August 1, 2022 | Categories: Award, Research, Uncategorized | Tagged: , ,

State-funded ISCRM Fellowships enable students at the undergraduate, graduate, and postdoctoral level to advance research efforts aimed at addressing the root causes of diseases. Read More

Deletion of Lamin B1 Linked to Nuclear Abnormalities Seen in Cancer

March 11, 2022 | Categories: Research, Uncategorized | Tagged: , ,

Using gene-editing tools to decrease expression of lamin B1 in two stem cell models, the researchers show that deletion of lamin B1 causes change in stem cell function and nuclear shape – and contributes to leukemia progression. Read More

Green and purple stained organoid

ISCRM Research Sheds New Light on COVID-19 and Kidney Health

December 2, 2021 | Categories: Core Faculty, Research, Uncategorized | Tagged: , , ,

ISCRM researchers use kidney organoids to demonstrate that COVID-19 is capable of infecting kidney cells directly and test whether a synthetic protein designed by the Institute for Protein Design (IPD) might be capable of preventing infection. Read More

grid of four young scientists

Meet the 2021-2022 ISCRM Fellows

September 14, 2021 | Categories: Uncategorized

The 2021-2022 ISCRM Fellows were selected from a deep pool of undergraduate students, PhD students, and postdoc. Each ISCRM Fellow has received a state-funded fellowship to support their research. Read More

Gene Editing May Help Address Arrhythmia Challenges in Heart Regeneration

June 21, 2021 | Categories: Heart Regeneration, Research, Uncategorized | Tagged: , , ,

New data presented by ISCRM Director Chuck Murry suggests gene-editing may be the key to clearing a major hurdle for researchers hoping to remuscularize injured hearts with stem cell-derived cardiomyocytes Read More