A man in glasses writes diagrams on a glass board with a marker while a woman watches and listens attentively in a brightly lit office or classroom setting.

Modeling a Muscle Disease in 3D

August 17, 2022 | Categories: Award, Core Faculty, Research, Uncategorized | Tagged: , ,

A team of investigators led by ISCRM faculty members David Mack, PhD and Nate Sniadecki, PhD have shown that is possible to recreate DMD with much more complexity in a 3D model of engineered heart tissue. Read More

Group of people standing outside

Meet the 2022-2023 ISCRM Fellows

August 1, 2022 | Categories: Award, Research, Uncategorized | Tagged: , ,

State-funded ISCRM Fellowships enable students at the undergraduate, graduate, and postdoctoral level to advance research efforts aimed at addressing the root causes of diseases. Read More

Two groups of stained neutrophil cells: the left group shows normal-shaped nuclei, while the right group shows nuclei with abnormal shapes, indicating lamin B1 deletion (Pelger-Huët anomaly).

Deletion of Lamin B1 Linked to Nuclear Abnormalities Seen in Cancer

March 11, 2022 | Categories: Research, Uncategorized | Tagged: , ,

Using gene-editing tools to decrease expression of lamin B1 in two stem cell models, the researchers show that deletion of lamin B1 causes change in stem cell function and nuclear shape – and contributes to leukemia progression. Read More

Green and purple stained organoid

ISCRM Research Sheds New Light on COVID-19 and Kidney Health

December 2, 2021 | Categories: Core Faculty, Research, Uncategorized | Tagged: , , ,

ISCRM researchers use kidney organoids to demonstrate that COVID-19 is capable of infecting kidney cells directly and test whether a synthetic protein designed by the Institute for Protein Design (IPD) might be capable of preventing infection. Read More

grid of four young scientists

Meet the 2021-2022 ISCRM Fellows

September 14, 2021 | Categories: Uncategorized

The 2021-2022 ISCRM Fellows were selected from a deep pool of undergraduate students, PhD students, and postdoc. Each ISCRM Fellow has received a state-funded fellowship to support their research. Read More

Three scientists wearing lab coats, gloves, and face masks review notes in a laboratory. Shelves with colorful binders and lab equipment are visible in the background.

Gene Editing May Help Address Arrhythmia Challenges in Heart Regeneration

June 21, 2021 | Categories: Heart Regeneration, Research, Uncategorized | Tagged: , , ,

New data presented by ISCRM Director Chuck Murry suggests gene-editing may be the key to clearing a major hurdle for researchers hoping to remuscularize injured hearts with stem cell-derived cardiomyocytes Read More

A woman in a black blazer and magenta top stands smiling in a library with wooden bookshelves and tables in the background.

ISCRM Welcomes Thelma Escobar

May 6, 2021 | Categories: Uncategorized

Thelma Escobar, PhD, joins the University of Washington as an Assistant Professor of Biochemistry and an ISCRM faculty member Read More

A person with red hair gestures while sitting in front of a computer displaying a colorful 3D model. A whiteboard with diagrams is in the background, and purple graphics border the image on the right.

Study Yields New Clue to Strokes of Undetermined Source

May 4, 2021 | Categories: Core Faculty, Research, Uncategorized | Tagged: , ,

Simulations shed light on heart-scarring similarities among patients with atrial fibrillation and those who had embolic stroke but no atrial fibrillation. Read More

Rainbow Heart

ISCRM Researchers Use Rainbow Reporters to Examine Proliferation of Engrafted Heart Cells

April 19, 2021 | Categories: Core Faculty, Heart Regeneration, Research, Uncategorized | Tagged: , , , ,

ISCRM investigators use rainbow cell technology to demonstrate that injected heart cells proliferate, a finding that could help researchers enhance the efficacy of cell therapy for heart disease and other conditions. Read More