News

Side-by-side portraits of a man in glasses and a white coat, smiling, and a woman with curly hair in a dark blazer, also smiling, both in professional settings.

Yang Lab Co-Leads NIH-Funded Effort to Improve Genetic Testing for HCM

November 4, 2024 | Categories: Research | Tagged: , , ,

An NIH-funded partnership between ISCRM faculty member Dr. Daniel Yang and Dr. Lea Starita in the UW Department of Genome Sciences will use an innovative gene editing technology to sequence large numbers of variants of a mutation associated with hypertrophic cardiomyopathy. Read More

Color-coded diagram of a protein structure with labeled regions: Upper 50 kDa (blue), Lower 50 kDa (light blue), Actin Binding Sites (green), Regulatory Loops (red), N-Terminal Domain (purple), Relay Helix (red), Converter Domain (orange).

How Small Molecules Have a Big Impact on the Heart

October 23, 2024 | Categories: Core Faculty, Research | Tagged: , , ,

Researchers at UW and UCSD use a multiscale modeling tool show how small infusions of myosin can have a big impact on the whole heart. Read More

Four panels show the same bone structure in blue, red, green, and purple against a black background, highlighting detailed textures and variations in the bone’s surface.

Modeling the Periodontal Ligament in 3D

October 22, 2024 | Categories: Core Faculty, Research | Tagged: ,

A new 3D modeling tool developed by the Sniadecki Lab and Dr. Tracy Popwics in the School of Dentistry could lead to regenerative therapies for periodontal diseases. Read More

Headshot of David Baker

David Baker Receives Nobel Prize

October 9, 2024 | Categories: Award, Core Faculty | Tagged:

ISRCRM faculty member David Baker has been awarded the 2024 Nobel Prize in Chemistry for computational protein design. Read More

Two men wearing white lab coats stand and smile in a laboratory. Shelves with lab equipment and supplies are visible in the background, and a window lets in natural light.

New Gene Therapy for Muscular Dystrophy Offers Hope

July 17, 2024 | Categories: Core Faculty, Research | Tagged: , ,

A new gene therapy treatment for Duchenne muscular dystrophy (DMD) shows promise of not only arresting the decline of the muscles of those affected by this inherited genetic disease, but perhaps, in the future, repairing those muscles. Read More

Three people wearing white lab coats closely examine scientific equipment on a lab bench, appearing focused and engaged in a laboratory setting.

Kelly Stevens to Co-Lead NIH Funded Center to Foster New Ideas and Fight Inequity

June 27, 2024 | Categories: Core Faculty | Tagged: ,

Kelly Stevens and Lola Eniola-Adefeso at the University of Michigan are co-leaders of a new NIH-funded center that will spur biomaterials translational solutions and bring together traditional, nontraditional, and historically excluded biomaterials researchers. Read More

Microscopic image showing a cell with branching white structures on the left, and a 3D molecular model with a white circular structure and pink segments on the right, set against a dark background.

Designed Proteins Guide Stem Cells to Form Blood Vessels

June 11, 2024 | Categories: Core Faculty, Research | Tagged: , ,

UW researchers have used computer-designed proteins to direct human stem cells to form new blood vessels in the lab, offering new hope for repairing damaged hearts, kidneys, and other organs. Read More

Side-by-side photos of two men: the left man with short light brown hair wearing a light purple shirt, and the right man with short dark curly hair wearing a dark polo shirt, smiling in a room with shelves behind him.

Meet the 2024 Tietze Award Winners

May 24, 2024 | Categories: Award, Core Faculty | Tagged: , ,

ISCRM Associate Director Nate Sniadecki, PhD, Professor of Mechanical Engineering and Hichem Tasfaout, PhD, Acting Assistant Professor, Neurology have received prestigious awards from the John H. Tietze Foundation Trust that will help fuel promising research underway in their labs. Read More

Illustration of microscopic muscle fibers and proteins, showing bundled orange filaments with spiral extensions and rows of green and purple molecules, representing molecular processes within muscle tissue.

Why Tiny Changes in Protein Structure Can Lead to Big Problems for the Heart

May 2, 2024 | Categories: Research, Uncategorized | Tagged: , , ,

An NIH-funded collaboration involving ISCRM researchers has published a study describing how complementary areas of expertise produced new insights about hypertrophic cardiomyopathy at the protein, cell, and tissue levels. Read More

Side-by-side images of PKD mini-kidneys: the untreated one (left) appears smoother, while the one given readthrough drug (right) looks more structured or textured. Each is about 1mm wide.

Freedman Lab Discovers Promising New Therapeutic for PKD in Tailor-Made Organoids

April 4, 2024 | Categories: Core Faculty, Research | Tagged: , , ,

In a new study published in Cell Stem Cell, the Freedman Lab shows that a drug known to be safe in humans inhibits the growth of cysts in gene-edited organoids with polycystic kidney disease. Read More

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