Freedman Lab Tests a Promising mTOR Inhibitor in PKD Organoids
January 23, 2025 | Categories: Research |The study results suggest the molecule at the center of the study may be safer at higher doses and therefore more potent against harmful cysts. Read More
Yang Lab Co-Leads NIH-Funded Effort to Improve Genetic Testing for HCM
November 4, 2024 | Categories: Research |An NIH-funded partnership between ISCRM faculty member Dr. Daniel Yang and Dr. Lea Starita in the UW Department of Genome Sciences will use an innovative gene editing technology to sequence large numbers of variants of a mutation associated with hypertrophic cardiomyopathy. Read More
How Small Molecules Have a Big Impact on the Heart
October 23, 2024 | Categories: Core Faculty, Research |Researchers at UW and UCSD use a multiscale modeling tool show how small infusions of myosin can have a big impact on the whole heart. Read More
Modeling the Periodontal Ligament in 3D
October 22, 2024 | Categories: Core Faculty, Research |A new 3D modeling tool developed by the Sniadecki Lab and Dr. Tracy Popwics in the School of Dentistry could lead to regenerative therapies for periodontal diseases. Read More
New Gene Therapy for Muscular Dystrophy Offers Hope
July 17, 2024 | Categories: Core Faculty, Research |A new gene therapy treatment for Duchenne muscular dystrophy (DMD) shows promise of not only arresting the decline of the muscles of those affected by this inherited genetic disease, but perhaps, in the future, repairing those muscles. Read More
Designed Proteins Guide Stem Cells to Form Blood Vessels
June 11, 2024 | Categories: Core Faculty, Research |UW researchers have used computer-designed proteins to direct human stem cells to form new blood vessels in the lab, offering new hope for repairing damaged hearts, kidneys, and other organs. Read More
Why Tiny Changes in Protein Structure Can Lead to Big Problems for the Heart
May 2, 2024 | Categories: Research, Uncategorized |An NIH-funded collaboration involving ISCRM researchers has published a study describing how complementary areas of expertise produced new insights about hypertrophic cardiomyopathy at the protein, cell, and tissue levels. Read More
Freedman Lab Discovers Promising New Therapeutic for PKD in Tailor-Made Organoids
April 4, 2024 | Categories: Core Faculty, Research |In a new study published in Cell Stem Cell, the Freedman Lab shows that a drug known to be safe in humans inhibits the growth of cysts in gene-edited organoids with polycystic kidney disease. Read More
Berndt Lab Machine Learning Model Sets a New Pace in Protein Sensor Design
March 26, 2024 | Categories: Core Faculty, Research |Over the course of a multiyear, collaborative investigation, researchers in the Berndt Lab showed that their trained machine learning models correctly predicted several variants of the calcium indicator GCaMP with record-setting speed and accuracy, outperforming all previous generations of these sensors. Read More
Protein-Based Biomaterial Protects Injected Cells, Improves Engraftment
March 13, 2024 | Categories: Core Faculty, Research |Research led by Cole DeForest, PhD in collaboration with Chuck Murry, MD, PhD and Kelly Stevens, PhD details a new protein-based biomaterial that could help improve engraftment and function following injectable cell therapies. Read More